Methimazole

45 interactions 127 cited references
Also sold as: Felanorm Felimazole Reguzol Tapazole®
About Methimazole

Methimazole is used to treat hyperthyroidism, a condition that occurs when the thyroid gland produces too much thyroid hormone. It is also taken before thyroid surgery or radioactive iodine therapy. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Read the full Methimazole drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Azathioprine Mercaptopurine Bupropion Levoketoconazole Methotrexate Tegafur
7 Major 37 Moderate 1 Minor
All (45) Major (7) Moderate (37) Minor (1)

Major

Methimazole Azathioprine Azasan An increased risk of hepatotoxicity Details Methimazole Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Methimazole Bupropion Aplenzin An increased risk of hepatotoxicity Details Methimazole Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Methimazole Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methimazole Tegafur Decreased exposure of 5-fluorouracil Details Methimazole Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Moderate

Methimazole Atenolol Tenormin Altered metabolism of the beta-adrenergic blocker Details Methimazole Acebutolol Sectral® Altered metabolism of the beta-adrenergic blocker Details Methimazole Betaxolol Betoptic S Altered metabolism of the beta-adrenergic blocker Details Methimazole Betaxolol Ophthalmic Betoptic® Altered metabolism of the beta-adrenergic blocker Details Methimazole Bisoprolol Zebeta® Altered metabolism of the beta-adrenergic blocker Details Methimazole Esmolol Brevibloc Altered metabolism of the beta-adrenergic blocker Details Methimazole Labetalol Normodyne® Altered metabolism of the beta-adrenergic blocker Details Methimazole Levobunolol Ophthalmic AKBeta® Altered metabolism of the beta-adrenergic blocker Details Methimazole Acenocoumarol Decreased anticoagulant effectiveness Details Methimazole Alprenolol Altered metabolism of the beta-adrenergic blocker Details Methimazole Anisindione Decreased anticoagulant effectiveness Details Methimazole Bevantolol Altered metabolism of the beta-adrenergic blocker Details Methimazole Bucindolol Altered metabolism of the beta-adrenergic blocker Details Methimazole Bugleweed Additive antithyroid effects Details Methimazole Carteolol Altered metabolism of the beta-adrenergic blocker Details Methimazole Carvedilol Coreg Altered metabolism of the beta-adrenergic blocker Details Methimazole Celiprolol Altered metabolism of the beta-adrenergic blocker Details Methimazole Dicumarol Decreased anticoagulant effectiveness Details Methimazole Dilevalol Altered metabolism of the beta-adrenergic blocker Details Methimazole Levobunolol Betagan Altered metabolism of the beta-adrenergic blocker Details Methimazole Mepindolol Altered metabolism of the beta-adrenergic blocker Details Methimazole Metipranolol Altered metabolism of the beta-adrenergic blocker Details Methimazole Metoprolol Kapspargo Altered metabolism of the beta-adrenergic blocker Details Methimazole Nadolol Corgard Altered metabolism of the beta-adrenergic blocker Details Methimazole Nebivolol Bystolic Altered metabolism of the beta-adrenergic blocker Details Methimazole Oxprenolol Altered metabolism of the beta-adrenergic blocker Details Methimazole Penbutolol Levatol® Altered metabolism of the beta-adrenergic blocker Details Methimazole Phenindione Decreased anticoagulant effectiveness Details Methimazole Phenprocoumon Decreased anticoagulant effectiveness Details Methimazole Pindolol Visken® Altered metabolism of the beta-adrenergic blocker Details Methimazole Propranolol Hemangeol Altered metabolism of the beta-adrenergic blocker Details Methimazole Sotalol Betapace Altered metabolism of the beta-adrenergic blocker Details Methimazole Talinolol Altered metabolism of the beta-adrenergic blocker Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.