Methotrexate Injection
354 interactions 996 cited referencesMethotrexate injection is used alone or in combination with other medications: to treat certain types of acute lymphocytic leukemia (ALL) in adults and children; to treat or prevent meningeal leukemia (cancer in the covering of the spinal cord and brain) in adults and children; to treat certain types of non-Hodgkin's l… Read the full Methotrexate Injection drug information page →
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Major
Methotrexate Injection Valproic Acid Depakene® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Venlafaxine Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Vimseltinib Romvimza Increased risk of BCRP substrate exposure Details Methotrexate Injection Vincristine Marqibo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Voclosporin Lupkynis Increased OATP1B1 substrate exposure Details Methotrexate Injection Voriconazole Vfend Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Warfarin Coumadin Increased risk for elevated INR and subsequent bleeding; increased methotrexate exposure, an increased risk of methotrexate-relate... Details Methotrexate Injection Zafirlukast Accolate Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Zidovudine Retrovir Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Zolpidem Ambien Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Methotrexate Injection Zonisamide Zonegran Increased methotrexate exposure, decreased metabolite formation and increased risk of adverse events and decreased efficacy Details Methotrexate Injection Zoster Vaccine, Live An increased risk of disseminated infections DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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