Methsuximide

Name: Methsuximide Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

12 interactions 47 cited references

Also sold as: Celontin Celontin®

About Methsuximide

Methsuximide is used to control absence seizures (petit mal; a type of seizure in which there is a very short loss of awareness during which the person may stare straight ahead or blink his eyes and does not respond to others) that cannot be treated with other medications. Methsuximide is in a class of medications call… Read the full Methsuximide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Calcifediol Hydroxychloroquine Fosphenytoin Orlistat Phenytoin Pimozide

6 Major 6 Moderate

All (12) Major (6) Moderate (6)

Major

Methsuximide Calcifediol Rayaldee Altered serum levels of calcifediol Details Methsuximide Hydroxychloroquine Plaquenil Impaired antiepileptic activity Details Methsuximide Fosphenytoin Cerebyx Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity (a... Details Methsuximide Orlistat Alli Reduced efficacy of anticonvulsant Details Methsuximide Phenytoin Dilantin Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity (a... Details Methsuximide Pimozide An increased risk of seizure Details

Moderate

Methsuximide Felbamate Felbatol Increased concentrations of methsuximide active metabolites Details Methsuximide Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Methsuximide Carbamazepine Carbatrol Reduced carBAMazepine exposure and reduced methsuximide exposure Details Methsuximide Evening Primrose Reduced anticonvulsant effectiveness Details Methsuximide Ginkgo Decreased anticonvulsant effectiveness Details Methsuximide Lamotrigine Lamictal Reduced lamotrigine concentrations and possible loss of seizure control Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.