Methylphenidate

71 interactions 302 cited references
Also sold as: Adhansia XR® Aptensio Aptensio XR® Concerta Concerta® Cotempla Cotempla® XR-ODT Daytrana Jornay Jornay PM® Metadate Metadate® CD Metadate® ER Methylin Methylin® Methylin® ER QuilliChew Quillichew® ER Quillivant Quillivant® XR Relexxii Ritalin Ritalin® Ritalin® LA Ritalin® SR
About Methylphenidate

A central nervous system stimulant used to treat ADHD and narcolepsy by changing brain chemical levels. Read the full Methylphenidate drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ozanimod Pimozide Linezolid Isocarboxazid Methylene Blue Phenelzine
12 Contraindicated 57 Major 2 Moderate
All (71) Contraindicated (12) Major (57) Moderate (2)

Major

Methylphenidate Pantoprazole Protonix Altered pharmacodynamic and changes in release profile of methylphenidate Details Methylphenidate Paroxetine Paxil Increased selective serotonin reuptake inhibitor exposure Details Methylphenidate Phenobarbital Fidoquel Increased PHENobarbital exposure Details Methylphenidate Phenprocoumon Increased coumarin anticoagulants exposure and an increased risk of bleeding Details Methylphenidate Phenytoin Dilantin Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure Details Methylphenidate Primidone Mysoline Increased PHENobarbital exposure Details Methylphenidate Rabeprazole Aciphex Altered pharmacodynamic and changes in release profile of methylphenidate Details Methylphenidate Ranitidine Altered pharmacodynamic and changes in release profile of methylphenidate Details Methylphenidate Ranitidine Bismuth Citrate Altered pharmacodynamic and changes in release profile of methylphenidate Details Methylphenidate Risperidone Perseris An increased risk of extrapyramidal symptoms Details Methylphenidate Roxatidine Altered pharmacodynamic and changes in release profile of methylphenidate Details Methylphenidate Sevoflurane Petrem Increased risk of sudden blood pressure and heart rate increases Details Methylphenidate Tramadol ConZip An increased risk of seizure Details Methylphenidate Vilazodone Viibryd Increased selective serotonin reuptake inhibitor exposure Details Methylphenidate Vortioxetine Trintellix Increased selective serotonin reuptake inhibitor exposure Details Methylphenidate Warfarin Coumadin Increased coumarin anticoagulants exposure and an increased risk of bleeding Details Methylphenidate Olodaterol Oral Inhalation Striverdi An increased risk of clinically significant cardiovascular effects and fatalities and an increased/potentiated sympathetic effects... Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.