Methylphenidate Interactions


Methylphenidate is used as part of a treatment program to control symptoms of attention deficit hyperactivity disorder (ADHD; more difficulty focusing, controlling actions, and remaining still or quiet than other people who are the same age) in adults and children. Methylphenidate (Methylin) is also used to treat narcolepsy (a sleep disorder that causes excessive daytime sleepiness and sudden attacks of sleep). Methylphenidate is in a class of medications called central nervous system (CNS) stimulants. It works by changing the amounts of certain natural substances in the brain.

See More information Regarding Methylphenidate

Brand Names Associated with Methylphenidate

  • Adhansia XR®
  • Aptensio XR®
  • Concerta®
  • Cotempla® XR-ODT
  • Jornay PM®
  • Metadate® CD
  • Metadate® ER
  • Methylin®
  • Methylin® ER
  • Methylphenidate
  • Methylphenidylacetate hydrochloride
  • Quillichew® ER
  • Quillivant® XR
  • Ritalin®
  • Ritalin® LA
  • Ritalin® SR

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The drugs below are categorized by the severity of their interaction (see description of categories at the bottom of the page).

Click the drug name (listed by the generic name) to view specific drug-drug interaction details.

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What Do The Severity Ratings Mean?

Contraindicated

These drugs, generally, should not be used together simultaneously due to the high risk of severe adverse effects. Combining these medications can lead to dangerous health outcomes and should be strictly avoided unless otherwise instructed by your provider.


Major

This interaction could result in very serious and potentially life-threatening consequences. If you are taking this drug combination, it is very important to be under close medical supervision to minimize severe side effects and ensure your safety. It may be necessary to change a medication or dosage to prevent harm.


Moderate

This interaction has the potential to worsen your medical condition or alter the effectiveness of your treatment. It's important that you are monitored closely and you potentially may need to make adjustments in your treatment plan or drug dosage to maintain optimal health.


Minor

While this interaction is unlikely to cause significant problems, it could intensify side effects or reduce the effectiveness of one or both medications. Monitoring for changes in symptoms and your condition is recommended, and adjustments may be made if needed to manage any increased or more pronounced side effects.


Disclaimer: The information provided on this page is for informational purposes only and should not be considered medical advice. Always consult with a qualified healthcare professional regarding your specific circumstances and medical conditions.

Drug interaction information is compilated from several drug compendia, including:

  • Gold Standard Drug Database
  • Micromedix
  • Lexicomp
  • PubMed

The information posted is fact-checked by HelloPharmacist clinicians and reviewed quarterly.