Methylphenidate

71 interactions 302 cited references
Also sold as: Adhansia XR® Aptensio Aptensio XR® Concerta Concerta® Cotempla Cotempla® XR-ODT Daytrana Jornay Jornay PM® Metadate Metadate® CD Metadate® ER Methylin Methylin® Methylin® ER QuilliChew Quillichew® ER Quillivant Quillivant® XR Relexxii Ritalin Ritalin® Ritalin® LA Ritalin® SR
About Methylphenidate

A central nervous system stimulant used to treat ADHD and narcolepsy by changing brain chemical levels. Read the full Methylphenidate drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ozanimod Pimozide Linezolid Isocarboxazid Methylene Blue Phenelzine
12 Contraindicated 57 Major 2 Moderate
All (71) Contraindicated (12) Major (57) Moderate (2)

Contraindicated

Methylphenidate Linezolid Injection Zyvox An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylphenidate Isocarboxazid Marplan An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylphenidate Linezolid Zyvox An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylphenidate Methylene Blue Provayblue An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylphenidate Ozanimod An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylphenidate Phenelzine Nardil An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylphenidate Pimozide An increased risk of motor and phonic tics Details Methylphenidate Procarbazine An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylphenidate Rasagiline Azilect An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylphenidate Safinamide Xadago An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylphenidate Selegiline Anipryl An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details Methylphenidate Tranylcypromine Parnate An increased risk of hypertensive crisis (headache, palpitation, and neck stiffness) Details

Major

Methylphenidate Omeprazole Gastrobim Altered pharmacodynamic and changes in release profile of methylphenidate Details Methylphenidate Sertraline Increased selective serotonin reuptake inhibitor exposure Details Methylphenidate Dexlansoprazole Dexilant Altered pharmacodynamic and changes in release profile of methylphenidate Details Methylphenidate Esomeprazole Nexium Altered pharmacodynamic and changes in release profile of methylphenidate Details Methylphenidate Esomeprazole Injection Nexium Altered pharmacodynamic and changes in release profile of methylphenidate Details Methylphenidate Famotidine Calmicid Altered pharmacodynamic and changes in release profile of methylphenidate Details Methylphenidate Famotidine Injection Calmicid Altered pharmacodynamic and changes in release profile of methylphenidate Details Methylphenidate Hydroxychloroquine Plaquenil An increased risk of seizures Details Methylphenidate Lansoprazole Prevacid Altered pharmacodynamic and changes in release profile of methylphenidate Details Methylphenidate Acenocoumarol Increased coumarin anticoagulants exposure and an increased risk of bleeding Details Methylphenidate Amifampridine Increased risk of seizures Details Methylphenidate Amphetamine Dexedrine Increased d-amphetamine in the brain and an increased risk of potentiated cardiovascular events Details Methylphenidate Bupropion Aplenzin Increased risk of seizures Details Methylphenidate Cimetidine Tagamet Altered pharmacodynamic and changes in release profile of methylphenidate Details Methylphenidate Citalopram Celexa Increased selective serotonin reuptake inhibitor exposure Details Methylphenidate Clomipramine Anafranil Increased clomiPRAMINE exposure, an increased risk of seizures and an increased risk of drug-drug interactions Details Methylphenidate Desflurane Suprane Increased risk of sudden blood pressure and heart rate increases Details Methylphenidate Desipramine Norpramin Increased desipramine exposure Details Methylphenidate Dextroamphetamine Dexedrine Increased d-amphetamine in the brain and an increased risk of potentiated cardiovascular events Details Methylphenidate Donepezil Adlarity Reduced seizure threshold Details Methylphenidate Ebrotidine Altered pharmacodynamic and changes in release profile of methylphenidate Details Methylphenidate Enflurane Increased risk of sudden blood pressure and heart rate increases Details Methylphenidate Escitalopram Lexapro Increased selective serotonin reuptake inhibitor exposure Details Methylphenidate Fluoxetine RECONCILE Increased selective serotonin reuptake inhibitor exposure Details Methylphenidate Fluvoxamine Increased selective serotonin reuptake inhibitor exposure Details Methylphenidate Fosphenytoin Cerebyx Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure Details Methylphenidate Halothane Increased risk of sudden blood pressure and heart rate increases Details Methylphenidate Imipramine Increased imipramine exposure Details

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