Metoclopramide

35 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lurasidone Amitriptyline Sertraline Aripiprazole Injection Asenapine Transdermal Patch Brexpiprazole
7 Contraindicated 26 Major 2 Moderate
All (35) Contraindicated (7) Major (26) Moderate (2)

Major

Metoclopramide Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of CNS depression Details Metoclopramide Buprenorphine Belbuca Explained Increased risk of CNS depression Details Metoclopramide Cabergoline Dostinex® Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Butorphanol Injection Butorphic Increased risk of CNS depression Details Metoclopramide Butorphanol Nasal Spray Stadol® NS Increased risk of CNS depression Details Metoclopramide Cyclosporine Injection Atopica Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Metoclopramide Cyclosporine Ophthalmic Cequa Increased cycloSPORINE exposure and an increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Metoclopramide Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Metoclopramide Diazepam Rectal Diastat Increased risk of CNS depression Details Metoclopramide Digoxin Cardoxin® Reduced digoxin exposure Details Metoclopramide Diphenhydramine Injection Banophen Increased risk of CNS depression Details Metoclopramide Diphenhydramine Topical Afterbite with Antihistamine Increased risk of CNS depression Details Metoclopramide Entacapone Comtan Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Fentanyl Transdermal Patch Duragesic® Increased risk of CNS depression Details Metoclopramide Hydromorphone Injection Dilaudid Increased risk of CNS depression Details Metoclopramide Hydromorphone Rectal available generically Increased risk of CNS depression Details Metoclopramide Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Risk of hyperglycemia Details Metoclopramide Insulin Detemir (Rdna Origin) Injection Levemir Risk of hyperglycemia Details Metoclopramide Insulin Glulisine (Rdna Origin) Injection Apidra Risk of hyperglycemia Details Metoclopramide Levodopa Oral Inhalation Inbrija Diminished effectiveness of metoclopramide and the dopaminergic agent Details Metoclopramide Linezolid Injection Zyvox Increased risk of hypertensive crisis Details Metoclopramide Midazolam Nasal Spray Nayzilam Increased risk of CNS depression Details Metoclopramide Midazolam Injection Nayzilam Increased risk of CNS depression Details Metoclopramide Morphine Injection Astramorph® PF Increased risk of CNS depression Details Metoclopramide Nalbuphine Injection Nubain® Increased risk of CNS depression Details Metoclopramide Opicapone Ongentys Diminished effectiveness of metoclopramide and the dopaminergic agent Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.