Metolazone

72 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Metolazone Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Metolazone Albuterol Oral Inhalation Accuneb® Explained An increased risk of ECG changes or hypokalemia Details Metolazone Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Metolazone Acarbose Prandase® Explained An increased risk of hyperglycemia and an increased insulin requirement Details Metolazone Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Metolazone Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Metolazone Aspirin Acuprin® Reduced diuretic effectiveness and possible nephrotoxicity Details Metolazone Aspirin Rectal Aspirin Reduced diuretic effectiveness and possible nephrotoxicity Details Metolazone Alogliptin Nesina An increased risk of hyperglycemia and an increased insulin requirement Details Metolazone Bromfenac Ophthalmic Bromday® Reduced diuretic effectiveness and possible nephrotoxicity Details Metolazone Canagliflozin Invokana An increased risk of hyperglycemia and an increased insulin requirement Details Metolazone Cefepime Injection Maxipime® An increased risk of nephrotoxicity Details Metolazone Dapagliflozin Farxiga An increased risk of hyperglycemia and an increased insulin requirement Details Metolazone Diclofenac Ophthalmic Voltaren® Eye Drops Reduced diuretic effectiveness and possible nephrotoxicity Details Metolazone Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced diuretic effectiveness and possible nephrotoxicity Details Metolazone Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced diuretic effectiveness and possible nephrotoxicity Details Metolazone Diclofenac Transdermal Patch Flector Reduced diuretic effectiveness and possible nephrotoxicity Details Metolazone Digoxin Cardoxin® Increased risk of digitalis toxicity (nausea, vomiting, arrhythmias) Details Metolazone Dulaglutide Injection Trulicity An increased risk of hyperglycemia and an increased insulin requirement Details Metolazone Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) An increased risk of hyperglycemia and an increased insulin requirement Details Metolazone Etodolac Lodine Reduced diuretic effectiveness and possible nephrotoxicity Details Metolazone Exenatide Injection Bydureon An increased risk of hyperglycemia and an increased insulin requirement Details Metolazone Fenoprofen Fenopron Reduced diuretic effectiveness and possible nephrotoxicity Details Metolazone Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Metolazone Flecainide Tambocor® Increased risk of electrolyte imbalance and subsequent cardiotoxicity Details Metolazone Flurbiprofen Ansaid Reduced diuretic effectiveness and possible nephrotoxicity Details Metolazone Flurbiprofen Ophthalmic Ocufen Reduced diuretic effectiveness and possible nephrotoxicity Details Metolazone Furosemide Injection Disal Increased risk of electrolyte and fluid imbalance Details Metolazone Glimepiride Amaryl An increased risk of hyperglycemia and an increased insulin requirement Details Metolazone Glipizide Glucotrol An increased risk of hyperglycemia and an increased insulin requirement Details Metolazone Hydromorphone Injection Dilaudid Reduced efficacy of diuretics Details Metolazone Hydromorphone Rectal available generically Reduced efficacy of diuretics Details Metolazone Ibuprofen Addaprin Reduced diuretic effectiveness and possible nephrotoxicity Details Metolazone Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) An increased risk of hyperglycemia and an increased insulin requirement Details Metolazone Insulin Detemir (Rdna Origin) Injection Levemir An increased risk of hyperglycemia and an increased insulin requirement Details Metolazone Insulin Glulisine (Rdna Origin) Injection Apidra An increased risk of hyperglycemia and an increased insulin requirement Details Metolazone Ketoprofen Actron® Reduced diuretic effectiveness and possible nephrotoxicity Details Metolazone Ketorolac Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Metolazone Ketorolac Injection Acular Reduced diuretic effectiveness and possible nephrotoxicity Details Metolazone Ketorolac Nasal Spray Sprix Reduced diuretic effectiveness and possible nephrotoxicity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.