Metreleptin

Name: Metreleptin Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

11 interactions

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Insulin Degludec (Rdna Origin) Injection Insulin Detemir (Rdna Origin) Injection Insulin Glulisine (Rdna Origin) Injection

3 Major 8 Moderate

All (11) Major (3) Moderate (8)

Major

Metreleptin Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Increased risk of hypoglycemia Details Metreleptin Insulin Detemir (Rdna Origin) Injection Levemir Increased risk of hypoglycemia Details Metreleptin Insulin Glulisine (Rdna Origin) Injection Apidra Increased risk of hypoglycemia Details

Moderate

Metreleptin Cyclosporine Injection Atopica Altered exposure to cycloSPORINE Details Metreleptin Cyclosporine Ophthalmic Cequa Altered exposure to cycloSPORINE Details Metreleptin Dihydroergotamine Injection DHE-45® Injection Altered exposure to dihydroergotamine Details Metreleptin Dihydroergotamine Nasal Spray Migranal Altered exposure to dihydroergotamine Details Metreleptin Fentanyl Transdermal Patch Duragesic® Altered exposure to fentanyl Details Metreleptin Glimepiride Amaryl Increased risk of hypoglycemia Details Metreleptin Glipizide Glucotrol Increased risk of hypoglycemia Details Metreleptin Nateglinide Starlix® Increased risk of hypoglycemia Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.