Metronidazole Injection

242 interactions 832 cited references

Also sold as: Flagyl Flagyl® I.V. Flagyl® I.V. RTU® Likmez MetroCream MetroGel MetroLotion Noritate Nuvessa Nydamax Rosadan Vandazole

About Metronidazole Injection

Metronidazole injection is used to treat certain skin, blood, bone, joint, gynecologic, and abdominal (stomach area) infections caused by bacteria. It is also used to treat endocarditis (infection of the heart lining and valves), meningitis (infection of the membranes that surround the brain and spinal cord), and certa… Read the full Metronidazole Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levoketoconazole Mesoridazine Pimozide Piperaquine Saquinavir Sparfloxacin

15 Contraindicated 214 Major 13 Moderate

All (242) Contraindicated (15) Major (214) Moderate (13)

Contraindicated

Metronidazole Injection Amprenavir An increased risk of propylene glycol toxicity (seizures, tachycardia, lactic acidosis, renal toxicity, hemolysis) Details Metronidazole Injection Bepridil An increased risk of QT interval prolongation Details Metronidazole Injection Cisapride Propulsid® Increased risk of QT interval prolongation Details Metronidazole Injection Disulfiram Antabuse An increased risk of psychotic reactions Details Metronidazole Injection Dronabinol Marinol Disulfiram-like reaction Details Metronidazole Injection Dronedarone Multaq Increased risk of QT interval prolongation Details Metronidazole Injection Levoketoconazole Recorlev An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Metronidazole Injection Mesoridazine An increased risk of QT interval prolongation Details Metronidazole Injection Pimozide An increased risk of QT interval prolongation Details Metronidazole Injection Piperaquine An increased risk of QT interval prolongation Details Metronidazole Injection Saquinavir An increased risk of QT interval prolongation Details Metronidazole Injection Sparfloxacin An increased risk of QT interval prolongation Details Metronidazole Injection Terfenadine An increased risk of QT interval prolongation Details Metronidazole Injection Thioridazine An increased risk of QT interval prolongation Details Metronidazole Injection Ziprasidone Geodon An increased risk of QT interval prolongation Details

Major

Metronidazole Injection Acenocoumarol An increased risk of bleeding Details Metronidazole Injection Adagrasib Krazati An increased risk of QT interval prolongation, torsade de pointes, polymorphic ventricular tachycardia, other serious arrhythmias Details Metronidazole Injection Alfuzosin UroXatral An increased risk of QT interval prolongation Details Metronidazole Injection Amiodarone Nexterone An increased risk of QT interval prolongation and torsade de pointes Details Metronidazole Injection Amisulpride Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Metronidazole Injection Amitriptyline Elavil An increased risk of QT interval prolongation Details Metronidazole Injection Anagrelide Agrylin An increased risk of QT interval prolongation Details Metronidazole Injection Apomorphine Apokyn An increased risk of QT interval prolongation Details Metronidazole Injection Aripiprazole Abilify An increased risk of QT interval prolongation Details Metronidazole Injection Aripiprazole Lauroxil Aristada An increased risk of QT interval prolongation Details Metronidazole Injection Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Metronidazole Injection Artemether An increased risk of QT interval prolongation Details Metronidazole Injection Asenapine Saphris An increased risk of QT interval prolongation Details Metronidazole Injection Astemizole An increased risk of QT interval prolongation Details Metronidazole Injection Atazanavir Reyataz An increased risk of QT interval prolongation Details Metronidazole Injection Azithromycin AzaSite An increased risk of QT interval prolongation Details Metronidazole Injection Bedaquiline Sirturo An increased risk of QT interval prolongation Details Metronidazole Injection Buprenorphine Belbuca An increased risk of QT interval prolongation Details Metronidazole Injection Bupropion Aplenzin Increased risk of seizures Details Metronidazole Injection Busulfan Busulfex Increased busulfan exposure and an increased risk of busulfan toxicity Details Metronidazole Injection Capecitabine Xeloda Increased exposure of 5-fluorouracil Details Metronidazole Injection Ceritinib Zykadia An increased risk of QT interval prolongation Details Metronidazole Injection Chloroquine Aralen® An increased risk of QT interval prolongation Details Metronidazole Injection Chlorpromazine An increased risk of QT interval prolongation Details Metronidazole Injection Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.