Metronidazole Topical

242 interactions 832 cited references

Also sold as: MetroCream® MetroGel MetroGel® MetroLotion® Noritate® Cream Nydamax Rosadan

About Metronidazole Topical

Metronidazole is used to treat rosacea (a skin disease that causes redness, flushing, and pimples on the face). Metronidazole is in a class of medications called nitroimidazole antimicrobials. It works by stopping the growth of bacteria. Read the full Metronidazole Topical drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mesoridazine Pimozide Piperaquine Saquinavir Sparfloxacin Terfenadine

15 Contraindicated 214 Major 13 Moderate

All (242) Contraindicated (15) Major (214) Moderate (13)

Contraindicated

Metronidazole Topical Amprenavir An increased risk of propylene glycol toxicity (seizures, tachycardia, lactic acidosis, renal toxicity, hemolysis) Details Metronidazole Topical Bepridil An increased risk of QT interval prolongation Details Metronidazole Topical Cisapride Propulsid® Increased risk of QT interval prolongation Details Metronidazole Topical Disulfiram Antabuse An increased risk of psychotic reactions Details Metronidazole Topical Dronabinol Marinol Disulfiram-like reaction Details Metronidazole Topical Dronedarone Multaq Increased risk of QT interval prolongation Details Metronidazole Topical Levoketoconazole Recorlev An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Metronidazole Topical Mesoridazine An increased risk of QT interval prolongation Details Metronidazole Topical Pimozide An increased risk of QT interval prolongation Details Metronidazole Topical Piperaquine An increased risk of QT interval prolongation Details Metronidazole Topical Saquinavir An increased risk of QT interval prolongation Details Metronidazole Topical Sparfloxacin An increased risk of QT interval prolongation Details Metronidazole Topical Terfenadine An increased risk of QT interval prolongation Details Metronidazole Topical Thioridazine An increased risk of QT interval prolongation Details Metronidazole Topical Ziprasidone Geodon An increased risk of QT interval prolongation Details

Major

Metronidazole Topical Acenocoumarol An increased risk of bleeding Details Metronidazole Topical Adagrasib Krazati An increased risk of QT interval prolongation, torsade de pointes, polymorphic ventricular tachycardia, other serious arrhythmias Details Metronidazole Topical Alfuzosin UroXatral An increased risk of QT interval prolongation Details Metronidazole Topical Amiodarone Nexterone An increased risk of QT interval prolongation and torsade de pointes Details Metronidazole Topical Amisulpride Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Metronidazole Topical Amitriptyline Elavil An increased risk of QT interval prolongation Details Metronidazole Topical Anagrelide Agrylin An increased risk of QT interval prolongation Details Metronidazole Topical Apomorphine Apokyn An increased risk of QT interval prolongation Details Metronidazole Topical Aripiprazole Abilify An increased risk of QT interval prolongation Details Metronidazole Topical Aripiprazole Lauroxil Aristada An increased risk of QT interval prolongation Details Metronidazole Topical Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Metronidazole Topical Artemether An increased risk of QT interval prolongation Details Metronidazole Topical Asenapine Saphris An increased risk of QT interval prolongation Details Metronidazole Topical Astemizole An increased risk of QT interval prolongation Details Metronidazole Topical Atazanavir Reyataz An increased risk of QT interval prolongation Details Metronidazole Topical Azithromycin AzaSite An increased risk of QT interval prolongation Details Metronidazole Topical Bedaquiline Sirturo An increased risk of QT interval prolongation Details Metronidazole Topical Buprenorphine Belbuca An increased risk of QT interval prolongation Details Metronidazole Topical Bupropion Aplenzin Increased risk of seizures Details Metronidazole Topical Busulfan Busulfex Increased busulfan exposure and an increased risk of busulfan toxicity Details Metronidazole Topical Capecitabine Xeloda Increased exposure of 5-fluorouracil Details Metronidazole Topical Ceritinib Zykadia An increased risk of QT interval prolongation Details Metronidazole Topical Chloroquine Aralen® An increased risk of QT interval prolongation Details Metronidazole Topical Chlorpromazine An increased risk of QT interval prolongation Details Metronidazole Topical Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.