Metronidazole

278 interactions 832 cited references
Also sold as: Flagyl Flagyl® Flagyl® 375 Flagyl® ER Likmez MetroCream MetroGel MetroLotion Noritate Nuvessa Nydamax Rosadan Vandazole
About Metronidazole

Metronidazole is an antibiotic used to treat bacterial and parasitic infections in various parts of the body, including the reproductive and gastrointestinal systems. Read the full Metronidazole drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Terfenadine Saquinavir Piperaquine Pimozide Thioridazine Sparfloxacin
15 Contraindicated 244 Major 19 Moderate
All (278) Contraindicated (15) Major (244) Moderate (19)

Major

Metronidazole Eribulin Injection Halaven An increased risk of QT interval prolongation Details Metronidazole Exenatide Injection Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Metronidazole Famotidine Calmicid An increased risk of QT interval prolongation Details Metronidazole Famotidine Injection Calmicid An increased risk of QT interval prolongation Details Metronidazole Felbamate Felbatol An increased risk of QT interval prolongation Details Metronidazole Flecainide Tambocor® An increased risk of QT interval prolongation Details Metronidazole Fluorouracil Adrucil Increased exposure of 5-fluorouracil Details Metronidazole Fluorouracil Injection Adrucil Increased exposure of 5-fluorouracil Details Metronidazole Fluorouracil Topical Carac Increased exposure of 5-fluorouracil Details Metronidazole Foscarnet Injection Foscavir An increased risk of QT interval prolongation Details Metronidazole Fostemsavir Rukobia Increased risk of torsade de pointes Details Metronidazole Galantamine Razadyne An increased risk of QT interval prolongation Details Metronidazole Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details Metronidazole Gemifloxacin Factive An increased risk of QT interval prolongation Details Metronidazole Glasdegib Daurismo Increased risk of QT interval prolongation Details Metronidazole Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Metronidazole Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation Details Metronidazole Granisetron Injection Granisol An increased risk of QT interval prolongation Details Metronidazole Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Metronidazole Hydroxychloroquine Plaquenil An increased risk of seizures and an increased risk of QT interval prolongation Details Metronidazole Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Metronidazole Ivabradine Corlanor An increased risk of QT interval prolongation Details Metronidazole Ketoconazole Topical Extina® Foam An increased risk of QT interval prolongation Details Metronidazole Lefamulin Xenleta Increased risk of QT interval prolongation Details Metronidazole Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Metronidazole Levofloxacin Levaquin An increased risk of QT interval prolongation Details Metronidazole Levofloxacin Injection Levaquin An increased risk of QT interval prolongation Details Metronidazole Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity (weakness, tremor, excessive thirst, confusion) Details Metronidazole Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Metronidazole Mefloquine Lariam® An increased risk of QT interval prolongation Details Metronidazole Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Metronidazole Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Metronidazole Acenocoumarol An increased risk of bleeding Details Metronidazole Adagrasib Krazati An increased risk of QT interval prolongation, torsade de pointes, polymorphic ventricular tachycardia, other serious arrhythmias Details Metronidazole Amiodarone Nexterone An increased risk of QT interval prolongation and torsade de pointes Details Metronidazole Amisulpride Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Metronidazole Apomorphine Apokyn An increased risk of QT interval prolongation Details Metronidazole Aripiprazole Abilify An increased risk of QT interval prolongation Details Metronidazole Aripiprazole Lauroxil Aristada An increased risk of QT interval prolongation Details Metronidazole Artemether An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.