Metronidazole

278 interactions 832 cited references

Also sold as: Flagyl Flagyl® Flagyl® 375 Flagyl® ER Likmez MetroCream MetroGel MetroLotion Noritate Nuvessa Nydamax Rosadan Vandazole

About Metronidazole

Metronidazole is an antibiotic used to treat bacterial and parasitic infections in various parts of the body, including the reproductive and gastrointestinal systems. Read the full Metronidazole drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Terfenadine Saquinavir Piperaquine Pimozide Thioridazine Sparfloxacin

15 Contraindicated 244 Major 19 Moderate

All (278) Contraindicated (15) Major (244) Moderate (19)

Contraindicated

Metronidazole Disulfiram Antabuse An increased risk of psychotic reactions Details Metronidazole Dronabinol Marinol Disulfiram-like reaction Details Metronidazole Amprenavir An increased risk of propylene glycol toxicity (seizures, tachycardia, lactic acidosis, renal toxicity, hemolysis) Details Metronidazole Bepridil An increased risk of QT interval prolongation Details Metronidazole Cisapride Propulsid® Increased risk of QT interval prolongation Details Metronidazole Dronedarone Multaq Increased risk of QT interval prolongation Details Metronidazole Levoketoconazole Recorlev An increased risk of QT interval prolongation and an increased risk of torsade de pointes Details Metronidazole Mesoridazine An increased risk of QT interval prolongation Details Metronidazole Pimozide An increased risk of QT interval prolongation Details Metronidazole Piperaquine An increased risk of QT interval prolongation Details Metronidazole Saquinavir An increased risk of QT interval prolongation Details Metronidazole Sparfloxacin An increased risk of QT interval prolongation Details Metronidazole Terfenadine An increased risk of QT interval prolongation Details Metronidazole Thioridazine An increased risk of QT interval prolongation Details Metronidazole Ziprasidone Geodon An increased risk of QT interval prolongation Details

Major

Metronidazole Amitriptyline Elavil An increased risk of QT interval prolongation Details Metronidazole Sertraline An increased risk of QT interval prolongation Details Metronidazole Buprenorphine Belbuca An increased risk of QT interval prolongation Details Metronidazole Relugolix Orgovyx Increased risk of QT interval prolongation Details Metronidazole Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Metronidazole Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Metronidazole Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Metronidazole Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation Details Metronidazole Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation Details Metronidazole Azithromycin AzaSite An increased risk of QT interval prolongation Details Metronidazole Alfuzosin UroXatral An increased risk of QT interval prolongation Details Metronidazole Anagrelide Agrylin An increased risk of QT interval prolongation Details Metronidazole Bedaquiline Sirturo An increased risk of QT interval prolongation Details Metronidazole Busulfan Injection Busulfex Increased busulfan exposure and an increased risk of busulfan toxicity Details Metronidazole Capecitabine Xeloda Increased exposure of 5-fluorouracil Details Metronidazole Chloroquine Aralen® An increased risk of QT interval prolongation Details Metronidazole Dasatinib Phyrago An increased risk of QT interval prolongation Details Metronidazole Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Metronidazole Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Metronidazole Disopyramide Norpace An increased risk of QT interval prolongation Details Metronidazole Dofetilide Tikosyn An increased risk of QT interval prolongation Details Metronidazole Dolasetron Anzemet An increased risk of QT interval prolongation Details Metronidazole Dolasetron Injection Anzemet An increased risk of QT interval prolongation Details Metronidazole Encorafenib Braftovi Increased risk of QT interval prolongation Details Metronidazole Entrectinib Rozlytrek An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.