Metronidazole

278 interactions 832 cited references

Also sold as: Flagyl Flagyl® Flagyl® 375 Flagyl® ER Likmez MetroCream MetroGel MetroLotion Noritate Nuvessa Nydamax Rosadan Vandazole

About Metronidazole

Metronidazole is an antibiotic used to treat bacterial and parasitic infections in various parts of the body, including the reproductive and gastrointestinal systems. Read the full Metronidazole drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Terfenadine Saquinavir Piperaquine Pimozide Thioridazine Sparfloxacin

15 Contraindicated 244 Major 19 Moderate

All (278) Contraindicated (15) Major (244) Moderate (19)

Major

Metronidazole Clozapine Clozaril An increased risk of QT interval prolongation Details Metronidazole Crizotinib Xalkori An increased risk of QT interval prolongation Details Metronidazole Cyclobenzaprine Amrix An increased risk of QT interval prolongation Details Metronidazole Dabrafenib Tafinlar An increased risk of QT interval prolongation Details Metronidazole Degarelix Firmagon Increased risk of QT interval prolongation Details Metronidazole Delamanid An increased risk of QT interval prolongation Details Metronidazole Desflurane Suprane An increased risk of QT interval prolongation Details Metronidazole Desipramine Norpramin An increased risk of QT interval prolongation Details Metronidazole Dexmedetomidine Dexased Increased risk of cardiac arrhythmias Details Metronidazole Domperidone An increased risk of QT interval prolongation Details Metronidazole Donepezil Adlarity Increased risk of QT-interval prolongation and torsade de pointes Details Metronidazole Dordaviprone An increased risk of QT interval prolongation Details Metronidazole Doxepin Prudoxin An increased risk of QT interval prolongation Details Metronidazole Doxifluridine Increased exposure of 5-fluorouracil Details Metronidazole Droperidol An increased risk of QT interval prolongation Details Metronidazole Ebastine An increased risk of QT interval prolongation Details Metronidazole Efavirenz An increased risk of QT interval prolongation Details Metronidazole Eribulin Halaven An increased risk of QT interval prolongation Details Metronidazole Erythromycin Erythrocin Stearate An increased risk of QT interval prolongation Details Metronidazole Escitalopram Lexapro An increased risk of QT interval prolongation Details Metronidazole Etrasimod Velsipity Increased risk of transient reduction in heart rate, AV conduction, QT interval prolongation and an increased risk of torsade de p... Details Metronidazole Exenatide Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Metronidazole Fexinidazole An increased risk of QT interval prolongation Details Metronidazole Fingolimod Gilenya An increased risk of QT interval prolongation Details Metronidazole Fluconazole Diflucan An increased risk of QT interval prolongation Details Metronidazole Fluoxetine RECONCILE An increased risk of QT interval prolongation Details Metronidazole Formoterol Perforomist An increased risk of QT interval prolongation Details Metronidazole Foscarnet Foscavir An increased risk of QT interval prolongation Details Metronidazole Fosfomycin Contepo An increased risk of QT interval prolongation Details Metronidazole Fosphenytoin Cerebyx An increased risk of fosphenytoin toxicity, reduced metroNIDAZOLE exposure and an increased risk of QT interval prolongation Details Metronidazole Gatifloxacin Zymaxid An increased risk of QT interval prolongation Details Metronidazole Gepirone Exxua An increased risk of QT interval prolongation and cardiac arrhythmias Details Metronidazole Gepotidacin Blujepa An increased risk of QT interval prolongation Details Metronidazole Givinostat Duvyzat Increased risk of QT interval prolongation and torsade de pointes Details Metronidazole Goserelin Increased risk of QT interval prolongation Details Metronidazole Granisetron An increased risk of QT interval prolongation Details Metronidazole Halofantrine An increased risk of QT interval prolongation Details Metronidazole Haloperidol An increased risk of QT interval prolongation Details Metronidazole Histrelin Supprelin Increased risk of QT interval prolongation Details Metronidazole Hydroquinidine An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.