Metronidazole

278 interactions 832 cited references

Also sold as: Flagyl Flagyl® Flagyl® 375 Flagyl® ER Likmez MetroCream MetroGel MetroLotion Noritate Nuvessa Nydamax Rosadan Vandazole

About Metronidazole

Metronidazole is an antibiotic used to treat bacterial and parasitic infections in various parts of the body, including the reproductive and gastrointestinal systems. Read the full Metronidazole drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Terfenadine Saquinavir Piperaquine Pimozide Thioridazine Sparfloxacin

15 Contraindicated 244 Major 19 Moderate

All (278) Contraindicated (15) Major (244) Moderate (19)

Major

Metronidazole Hydroxyzine An increased risk of QT interval prolongation Details Metronidazole Ibutilide Corvert An increased risk of QT interval prolongation Details Metronidazole Iloperidone Fanapt An increased risk of QT interval prolongation Details Metronidazole Imipramine An increased risk of QT interval prolongation Details Metronidazole Inotuzumab Ozogamicin Besponsa Increased risk of QT interval prolongation Details Metronidazole Isoflurane Fluriso An increased risk of QT interval prolongation and torsade de pointes Details Metronidazole Itraconazole Sporanox An increased risk of QT interval prolongation Details Metronidazole Ivosidenib Tibsovo An increased risk of QT interval prolongation Details Metronidazole Ketoconazole Extina An increased risk of QT interval prolongation Details Metronidazole Lapatinib Tykerb An increased risk of QT interval prolongation Details Metronidazole Leuprolide Eligard Increased risk of QT interval prolongation Details Metronidazole Lithium Increased lithium exposure and an increased risk of lithium toxicity (weakness, tremor, excessive thirst, confusion) Details Metronidazole Lofexidine Increased risk of QT interval prolongation Details Metronidazole Lonafarnib Zokinvy An increased risk of QT interval prolongation and torsade de pointes Details Metronidazole Lumefantrine An increased risk of QT interval prolongation Details Metronidazole Macimorelin Increased risk of QT interval prolongation Details Metronidazole Mavorixafor Xolremdi An increased risk of QT interval prolongation and torsade de pointes Details Metronidazole Mebendazole Emverm Increased risk of Stevens-Johnson syndrome and/or toxic epidermal necrolysis Details Metronidazole Methadone Diskets An increased risk of QT interval prolongation Details Metronidazole Methotrimeprazine An increased risk of QT interval prolongation Details Metronidazole Mifepristone Korlym An increased risk of QT interval prolongation Details Metronidazole Milsaperidone An increased risk of QT interval prolongation Details Metronidazole Mirtazapine Mirataz An increased risk of QT interval prolongation Details Metronidazole Mizolastine An increased risk of QT interval prolongation Details Metronidazole Mobocertinib Exkivity An increased risk of QT interval prolongation Details Metronidazole Moricizine An increased risk of QT interval prolongation Details Metronidazole Moxifloxacin Avelox An increased risk of QT interval prolongation Details Metronidazole Mycophenolate Mofetil Decreased mycophenolate plasma exposure and possible reduced efficacy Details Metronidazole Mycophenolic Acid Myfortic Decreased mycophenolate plasma exposure and possible reduced efficacy Details Metronidazole Nelfinavir Viracept An increased risk of QT interval prolongation Details Metronidazole Nilotinib An increased risk of QT interval prolongation Details Metronidazole Norfloxacin An increased risk of QT interval prolongation Details Metronidazole Octreotide Bynfezia An increased risk of QT interval prolongation Details Metronidazole Ofloxacin Floxin® An increased risk of QT interval prolongation Details Metronidazole Olanzapine An increased risk of QT interval prolongation Details Metronidazole Olodaterol Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Metronidazole Ondansetron An increased risk of QT interval prolongation Details Metronidazole Osilodrostat Isturisa Increased risk of QT interval prolongation Details Metronidazole Osimertinib Tagrisso Increased risk of QT interval prolongation Details Metronidazole Oxaliplatin Increased risk of QT-interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.