Metronidazole

278 interactions 832 cited references
Also sold as: Flagyl Flagyl® Flagyl® 375 Flagyl® ER Likmez MetroCream MetroGel MetroLotion Noritate Nuvessa Nydamax Rosadan Vandazole
About Metronidazole

Metronidazole is an antibiotic used to treat bacterial and parasitic infections in various parts of the body, including the reproductive and gastrointestinal systems. Read the full Metronidazole drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Terfenadine Saquinavir Piperaquine Pimozide Thioridazine Sparfloxacin
15 Contraindicated 244 Major 19 Moderate
All (278) Contraindicated (15) Major (244) Moderate (19)

Major

Metronidazole Moricizine An increased risk of QT interval prolongation Details Metronidazole Moxifloxacin Avelox An increased risk of QT interval prolongation Details Metronidazole Mycophenolate Mofetil Decreased mycophenolate plasma exposure and possible reduced efficacy Details Metronidazole Mycophenolic Acid Myfortic Decreased mycophenolate plasma exposure and possible reduced efficacy Details Metronidazole Nelfinavir Viracept An increased risk of QT interval prolongation Details Metronidazole Nilotinib An increased risk of QT interval prolongation Details Metronidazole Norfloxacin An increased risk of QT interval prolongation Details Metronidazole Octreotide Bynfezia An increased risk of QT interval prolongation Details Metronidazole Ofloxacin Floxin® An increased risk of QT interval prolongation Details Metronidazole Olanzapine An increased risk of QT interval prolongation Details Metronidazole Olodaterol Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Metronidazole Ondansetron An increased risk of QT interval prolongation Details Metronidazole Osilodrostat Isturisa Increased risk of QT interval prolongation Details Metronidazole Osimertinib Tagrisso Increased risk of QT interval prolongation Details Metronidazole Oxaliplatin Increased risk of QT-interval prolongation Details Metronidazole Ozanimod Additive effects on heart rate Details Metronidazole Pacritinib Vonjo® An increased risk of QT interval prolongation Details Metronidazole Paliperidone Erzofri An increased risk of QT interval prolongation Details Metronidazole Panobinostat Farydak Increased risk of QT interval prolongation Details Metronidazole Papaverine Pavacot® An increased risk of QT interval prolongation Details Metronidazole Paroxetine Paxil An increased risk of QT interval prolongation Details Metronidazole Pasireotide Signifor An increased risk of QT interval prolongation Details Metronidazole Pazopanib Votrient An increased risk of QT-interval prolongation Details Metronidazole Pentamidine NebuPent An increased risk of QT interval prolongation Details Metronidazole Perphenazine An increased risk of QT interval prolongation Details Metronidazole Phenobarbital Fidoquel An increased risk of QT interval prolongation, reduced metroNIDAZOLE exposure and reduced metroNIDAZOLE efficacy Details Metronidazole Phenprocoumon An increased risk of bleeding Details Metronidazole Phenytoin Dilantin An increased risk of phenytoin toxicity or reduced metroNIDAZOLE exposure Details Metronidazole Pimavanserin Nuplazid An increased risk of QT interval prolongation Details Metronidazole Pipamperone An increased risk of QT interval prolongation Details Metronidazole Pitolisant Wakix Increased risk of QT interval prolongation Details Metronidazole Ponesimod Ponvory An increased risk of QT interval prolongation Details Metronidazole Posaconazole Noxafil An increased risk of QT interval prolongation Details Metronidazole Primidone Mysoline An increased risk of QT interval prolongation, reduced metroNIDAZOLE exposure and reduced metroNIDAZOLE efficacy Details Metronidazole Probucol An increased risk of QT interval prolongation Details Metronidazole Procainamide Procan® An increased risk of QT interval prolongation Details Metronidazole Prochlorperazine An increased risk of QT interval prolongation Details Metronidazole Promethazine Phenadoz An increased risk of QT interval prolongation Details Metronidazole Propafenone Rythmol An increased risk of QT interval prolongation Details Metronidazole Protriptyline An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.