Metronidazole

278 interactions 832 cited references

Also sold as: Flagyl Flagyl® Flagyl® 375 Flagyl® ER Likmez MetroCream MetroGel MetroLotion Noritate Nuvessa Nydamax Rosadan Vandazole

About Metronidazole

Metronidazole is an antibiotic used to treat bacterial and parasitic infections in various parts of the body, including the reproductive and gastrointestinal systems. Read the full Metronidazole drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Terfenadine Saquinavir Piperaquine Pimozide Thioridazine Sparfloxacin

15 Contraindicated 244 Major 19 Moderate

All (278) Contraindicated (15) Major (244) Moderate (19)

Major

Metronidazole Sodium Phosphate, Dibasic An increased risk of QT interval prolongation Details Metronidazole Sodium Phosphate, Monobasic An increased risk of QT interval prolongation Details Metronidazole Solifenacin Vesicare An increased risk of QT interval prolongation Details Metronidazole Sorafenib Nexavar An increased risk of QT interval prolongation Details Metronidazole Sotalol Betapace An increased risk of QT interval prolongation Details Metronidazole Sulpiride An increased risk of QT interval prolongation Details Metronidazole Sultopride An increased risk of QT interval prolongation Details Metronidazole Sunitinib Sutent An increased risk of QT interval prolongation Details Metronidazole Tacrolimus Astagraf Increased risk of QT-interval prolongation and arrhythmia; increased serum tacrolimus concentration and toxicity Details Metronidazole Taletrectinib Ibtrozi Increased risk of QT interval prolongation and torsade de pointes Details Metronidazole Tamoxifen Nolvadex® An increased risk of QT interval prolongation Details Metronidazole Tegafur Increased exposure of 5-fluorouracil Details Metronidazole Telaprevir An increased risk of QT interval prolongation Details Metronidazole Telavancin Vibativ An increased risk of QT interval prolongation Details Metronidazole Telithromycin An increased risk of QT interval prolongation Details Metronidazole Tetrabenazine Xenazine An increased risk of QT interval prolongation Details Metronidazole Tolterodine Detrol An increased risk of QT interval prolongation Details Metronidazole Toremifene Fareston An increased risk of QT interval prolongation Details Metronidazole Tramadol ConZip An increased risk of seizure Details Metronidazole Trazodone Raldesy An increased risk of QT interval prolongation Details Metronidazole Triclabendazole Egaten An increased risk of QT interval prolongation Details Metronidazole Trimipramine An increased risk of QT interval prolongation Details Metronidazole Triptorelin Increased risk of QT interval prolongation Details Metronidazole Vandetanib Caprelsa An increased risk of QT interval prolongation Details Metronidazole Vardenafil Levitra An increased risk of QT interval prolongation Details Metronidazole Vemurafenib Zelboraf An increased risk of QT interval prolongation Details Metronidazole Venlafaxine An increased risk of QT interval prolongation Details Metronidazole Vepdegestrant Veppanu An increased risk of QT interval prolongation and an increased risk of torsade de pointes, polymorphic ventricular tachycardia, ot... Details Metronidazole Vilanterol An increased risk of QT interval prolongation Details Metronidazole Vinflunine An increased risk of QT interval prolongation Details Metronidazole Voclosporin Lupkynis An increased risk of QT interval prolongation Details Metronidazole Voriconazole Vfend An increased risk of QT interval prolongation Details Metronidazole Vorinostat Zolinza An increased risk of QT interval prolongation Details Metronidazole Warfarin Coumadin Increased warfarin exposure and INR, and an increased risk of bleeding Details Metronidazole Ziftomenib Komzifti An increased risk of QT interval prolongation and torsade de pointes Details Metronidazole Zotepine An increased risk of QT interval prolongation Details Metronidazole Zuclopenthixol An increased risk of QT interval prolongation Details Metronidazole Moxifloxacin Injection Avelox An increased risk of QT interval prolongation Details Metronidazole Moxifloxacin Ophthalmic Moxeza® An increased risk of QT interval prolongation Details Metronidazole Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.