Miconazole Buccal

37 interactions 192 cited references

Also sold as: Oravig Oravig®

About Miconazole Buccal

Buccal miconazole is used to treat yeast infections of the mouth and throat in adults and children 16 years of age and older. Miconazole buccal is in a class of medications called imidazoles. It works by stopping the growth of fungi that cause infection. Read the full Miconazole Buccal drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Deuruxolitinib Pimozide Amiodarone Carvedilol Celecoxib Cilostazol

2 Contraindicated 22 Major 13 Moderate

All (37) Contraindicated (2) Major (22) Moderate (13)

Contraindicated

Miconazole Buccal Deuruxolitinib Increased deuruxolitinib exposure and an increased risk of deuruxolitinib-related adverse effects such as thrombosis Details Miconazole Buccal Pimozide An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details

Major

Miconazole Buccal Amiodarone Nexterone Increased amiodarone exposure Details Miconazole Buccal Carvedilol Coreg Increased carvedilol concentrations and an increased risk of bradycardia or heart block Details Miconazole Buccal Celecoxib Celebrex Increased celecoxib exposure Details Miconazole Buccal Cilostazol Pletal® Increased cilostazol exposure Details Miconazole Buccal Domperidone Increased domperidone exposure and an increased risk of QT interval prolongation Details Miconazole Buccal Erdafitinib Balversa Increased erdafitinib exposure Details Miconazole Buccal Escitalopram Lexapro Increased risk of serotonin syndrome (hypertension, tachycardia, hyperthermia, myoclonus, mental status changes) Details Miconazole Buccal Etonogestrel Nexplanon Increased etonogestrel exposure Details Miconazole Buccal Fosphenytoin Cerebyx Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity (a... Details Miconazole Buccal Glimepiride Amaryl Severe hypoglycemia Details Miconazole Buccal Ifosfamide Ifex Decreased ifosfamide effectiveness Details Miconazole Buccal Meloxicam Alloxate Increased meloxicam exposure and reduced meloxicam metabolic clearance Details Miconazole Buccal Methadone Diskets Increased methadone exposure and an increased risk of opioid adverse effects Details Miconazole Buccal Naloxegol Movantik Increased naloxegol exposure Details Miconazole Buccal Olaparib Lynparza Increased olaparib exposure Details Miconazole Buccal Phenobarbital Fidoquel Increased PHENobarbital exposure and an increased risk of PHENobarbital-related adverse effects Details Miconazole Buccal Phenytoin Dilantin Increased phenytoin or fosphenytoin (prodrug of phenytoin) exposure and an increased risk of phenytoin or fosphenytoin toxicity (a... Details Miconazole Buccal Piperaquine Increased exposure of piperaquine Details Miconazole Buccal Primidone Mysoline Increased PHENobarbital exposure and an increased risk of PHENobarbital-related adverse effects Details Miconazole Buccal Simeprevir Olysio® Increased simeprevir exposure Details Miconazole Buccal Voriconazole Vfend Increased voriconazole exposure Details Miconazole Buccal Warfarin Coumadin Increased warfarin exposure, an increased INR and an increased risk of bleeding Details

Moderate

Miconazole Buccal Aceclofenac Increased exposure of diclofenac Details Miconazole Buccal Acenocoumarol An increased risk of bleeding Details Miconazole Buccal Anisindione Increased risk of bleeding Details Miconazole Buccal Cyclosporine Atopica An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Details Miconazole Buccal Diclofenac Aleve Arthritis Pain Increased exposure of diclofenac Details Miconazole Buccal Dicumarol An increased risk of bleeding Details Miconazole Buccal Ethinyl Estradiol Increased exposure to ethinyl estradiol Details Miconazole Buccal Nateglinide Starlix® Increased risk of hypoglycemia Details Miconazole Buccal Oxybutynin Ditropan Increased oxybutynin exposure or plasma concentrations Details Miconazole Buccal Phenindione An increased risk of bleeding Details Miconazole Buccal Phenprocoumon Increased risk of bleeding Details Miconazole Buccal Tolterodine Detrol Enhanced tolterodine bioavailability in individuals with deficient cytochrome P450 2D6 activity Details Miconazole Buccal Trimetrexate Increased trimetrexate toxicity (bone marrow suppression, renal & hepatic dysfunction, and gastrointestinal ulceration) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.