Minoxidil and Etoricoxib: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Minoxidil
Etoricoxib
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased exposure to minoxidil
Interaction Deep Dive
Etoricoxib inhibits human sulfotransferase activity (particularly that of SULT1E1 substrates), and increases serum ethinyl estradiol concentrations, a human sulfotransferase substrate. Therefore, coadministration of etoricoxib and minoxidil, another human sulfotransferase substrate, may also increase the exposure of minoxidil. Use caution if concurrently administration is required1.
Why it happens (mechanism)
Reduction in human sulfotransferase-mediated minoxidil metabolism by etoricoxib
Common questions
Can I take Minoxidil and Etoricoxib together?
Increased exposure to minoxidil Always confirm with your pharmacist or prescriber before making any change.
How serious is the Minoxidil and Etoricoxib interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Minoxidil or Etoricoxib need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- eMC: Arcoxia 30mg, 60mg, 90mg & 120mg film-coated tablets, SPC dated November 2012. Datapharm Communications Ltd. Surrey, United Kingdom. 2013.
Keep reading about Etoricoxib
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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