Miokamycin and Cyclosporine Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Cyclosporine Injection
Miokamycin
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias)
Interaction Deep Dive
Miokamycin, when added to a cycloSPORINE regimen, has been associated with a two-fold increase in cycloSPORINE concentrations124.
Why it happens (mechanism)
Unknown
Literature reports
2 reports — tap to read
a) In a crossover study performed in 10 renal transplant patients, the effect of miokamycin 1600 mg daily administered for three days on the pharmacokinetic profile of cycloSPORINE 2.67 mg/kg/day was investigated. A statistically significant increase in maximum concentration (Cmax), minimum concentration (Cmin), area under the concentration-time curve (AUC) and in mean steady-state concentrations of cycloSPORINE during multiple dosing was observed 12.
b) Miokamycin significantly increased cycloSPORINE levels in renal transplant patients. After the administration of miokamycin 800 mg every 12 hours for two days, the average blood level of cycloSPORINE doubled. It is not known if the absorption of cycloSPORINE was increased or its metabolism decreased 3.
Common questions
Can I take Miokamycin and Cyclosporine Injection together?
An increased risk of cycloSPORINE toxicity (renal dysfunction, cholestasis, paresthesias) Always confirm with your pharmacist or prescriber before making any change.
How serious is the Miokamycin and Cyclosporine Injection interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "delayed". Effects tend to build up gradually over days to weeks.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
Questions for your pharmacist
- Does my dose of Miokamycin or Cyclosporine Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (4)
- Periti P, Mazzei T, Mini E, et al: Pharmacokinetic drug interactions of macrolides. Clin Pharmacokinet 1992; 23(2):106-131. PubMed
- von Rosenstiel NA & Adam D: Macrolide antibacterials. Drug interactions of clinical significance. Drug Saf 1995; 13(2):105-122. DOI
- Couet W, Istin B, Seniuta P, et al: Effect of ponsinomycin on cyclosporin pharmacokinetics. Eur J Clin Pharmacol 1990; 39:165-167. PubMed
- Product Information: Miokacin(R), miocamycin. F.I.R.M.A. SpA, Florence, Italy, 1996.
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