Mitapivat
295 interactions 80 cited referencesMitapivat is used to treat hemolytic anemia (a blood disorder that occurs when red blood cells are destroyed faster than they can be made in the body) in people with pyruvate kinase deficiency. Mitapivat is in a class of medications called pyruvate kinase activators. It works by increasing pyruvate kinase available to… Read the full Mitapivat drug information page →
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Major
Mitapivat Clindamycin ANTIROBE Reduced CYP3A substrate exposure Details Mitapivat Colchicine Colcrys Increased P-gp substrate exposure; reduced CYP3A substrate exposure Details Mitapivat Simvastatin Flolipid Reduced CYP3A substrate exposure Details Mitapivat Abemaciclib Verzenio Reduced CYP3A substrate exposure Details Mitapivat Acalabrutinib Calquence Reduced CYP3A substrate exposure Details Mitapivat Atogepant Qulipta Reduced atogepant exposure Details Mitapivat Avapritinib Ayvakit Reduced avapritinib exposure and reduced efficacy of avapritinib Details Mitapivat Cariprazine Vraylar Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Mitapivat Aficamten Reduced aficamten exposure and reduced efficacy of aficamten Details Mitapivat Amlodipine Amvaz® Reduced amLODIPine exposure Details Mitapivat Avanafil Stendra Reduced CYP3A substrate exposure Details Mitapivat Axitinib Inlyta Reduced CYP3A substrate exposure Details Mitapivat Bosutinib Bosulif Reduced CYP3A substrate exposure Details Mitapivat Brigatinib Alunbrig Reduced CYP3A substrate exposure Details Mitapivat Budesonide Entocort Reduced CYP3A substrate exposure Details Mitapivat Budesonide Nasal Spray Rhinocort Reduced CYP3A substrate exposure Details Mitapivat Budesonide Oral Inhalation Pulmicort Reduced CYP3A substrate exposure Details Mitapivat Cabozantinib Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Mitapivat Cabozantinib (Thyroid Cancer) Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Mitapivat Clindamycin Injection ANTIROBE Reduced CYP3A substrate exposure Details Mitapivat Clindamycin Topical C/T/S® Reduced CYP3A substrate exposure Details Mitapivat Clindamycin Vaginal Cleocin Reduced CYP3A substrate exposure Details Mitapivat Cobimetinib Cotellic Reduced CYP3A substrate exposure Details Mitapivat Cyclosporine Injection Atopica Increased P-gp substrate exposure; reduced CYP3A substrate exposure Details Mitapivat Cyclosporine Ophthalmic Cequa Increased P-gp substrate exposure; reduced CYP3A substrate exposure Details Mitapivat Dasatinib Phyrago Reduced CYP3A substrate exposure Details Mitapivat Dihydroergotamine Injection DHE-45® Injection Reduced CYP3A substrate exposure Details Mitapivat Dihydroergotamine Nasal Spray Migranal Reduced CYP3A substrate exposure Details Mitapivat Docetaxel Beizray Reduced CYP3A substrate exposure Details Mitapivat Docetaxel Injection Beizray Reduced CYP3A substrate exposure Details Mitapivat Dofetilide Tikosyn Reduced CYP3A substrate exposure Details Mitapivat Doravirine Pifeltro Reduced doravirine exposure and reduced efficacy of doravirine Details Mitapivat Elacestrant Orserdu Reduced CYP3A substrate exposure Details Mitapivat Encorafenib Braftovi Reduced mitapivat exposure and reduced efficacy of mitapivat Details Mitapivat Entrectinib Rozlytrek Reduced CYP3A substrate exposure Details Mitapivat Estradiol Delestrogen Reduced hormonal contraceptive exposure Details Mitapivat Estradiol Topical Divigel Reduced hormonal contraceptive exposure Details Mitapivat Estradiol Transdermal Patch Alora® Reduced hormonal contraceptive exposure Details Mitapivat Everolimus Afinitor Increased P-gp substrate exposure; reduced CYP3A substrate exposure Details Mitapivat Felodipine Plendil® Reduced CYP3A substrate exposure DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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