Mitomycin and Hexaminolevulinate: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Mitomycin
Hexaminolevulinate
No brand names on record
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased risk of false positive cytoscopy results
Interaction Deep Dive
Concomitant use of hexaminolevulinate and intravesical chemotherapy may result in a false positive fluorescence during cytoscopy. When treated with recent BCG immunotherapy or intravesical chemotherapy, the rate of false positives with blue light was 55% between 6 weeks to 90 days and 41% after 90 days. With white light, the rate of false positives were 53% and 33% at 6 weeks to 90 days1.
Why it happens (mechanism)
Unknown
Common questions
Can I take Mitomycin and Hexaminolevulinate together?
Increased risk of false positive cytoscopy results Always confirm with your pharmacist or prescriber before making any change.
How serious is the Mitomycin and Hexaminolevulinate interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "established". Well documented — supported by controlled studies or strong clinical data.
Questions for your pharmacist
- Does my dose of Mitomycin or Hexaminolevulinate need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: CYSVIEW(R) intravesical solution, hexaminolevulinate HCl intravesical solution. Photocure Inc. (per FDA), Princeton, NJ, 2018.
Keep reading about Mitomycin
Keep reading about Hexaminolevulinate
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Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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