Mobocertinib and Oxaliplatin Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 9, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Mobocertinib
Oxaliplatin Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of QT interval prolongation
Interaction Deep Dive
Coadministration of mobocertinib with drugs known to prolong the corrected QT (QTc) interval may increase the risk of QTc interval prolongation, including torsades de pointes, which can be fatal. Avoid concomitant use of other medications known to prolong the QTc interval with mobocertinib. If concomitant use is unavoidable, monitor the QTc interval more frequently with ECGs1.
Why it happens (mechanism)
Additive QT interval prolongation
Common questions
Can I take Mobocertinib and Oxaliplatin Injection together?
An increased risk of QT interval prolongation Always confirm with your pharmacist or prescriber before making any change.
How serious is the Mobocertinib and Oxaliplatin Injection interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Mobocertinib or Oxaliplatin Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: EXKIVITY(TM) oral capsules, mobocertinib oral capsules. Takeda Pharmaceuticals America Inc (per FDA), Lexington, MA, 2021.
Keep reading about Mobocertinib
Keep reading about Oxaliplatin Injection
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist