Morphine

73 interactions 6 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Glycopyrronium Topical Palonosetron Injection Naloxone Naloxone Injection Midazolam Injection

1 Contraindicated 68 Major 4 Moderate

All (73) Contraindicated (1) Major (68) Moderate (4)

Major

Morphine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Morphine Granisetron Injection Granisol Increased risk of serotonin syndrome Details Morphine Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Hydroxychloroquine Plaquenil An increased risk of seizures Details Morphine Ibrexafungerp Brexafemme Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Ipratropium Nasal Spray Atrovent Nasal Spray® Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Ipratropium Oral Inhalation Atrovent® HFA Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Istradefylline Nourianz Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Ketoconazole Topical Extina® Foam Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Lacosamide Injection Motpoly An increased risk of CNS depression Details Morphine Lenacapavir Injection Sunlenca Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Lenacapavir Oral Sunlenca Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Morphine Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Morphine Methylnaltrexone Relistor Decreased opioid efficacy and precipitation of opioid withdrawal Details Morphine Methylnaltrexone Injection Relistor Decreased opioid efficacy and precipitation of opioid withdrawal Details Morphine Metoclopramide Injection Gimoti Increased risk of CNS depression Details Morphine Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Morphine Midazolam Nasal Spray Nayzilam Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Midazolam Injection Nayzilam Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Nalbuphine Injection Nubain® Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Morphine Naloxone Kloxxado Decreased opioid efficacy and precipitation of opioid withdrawal Details Morphine Naloxone Injection Evzio® Decreased opioid efficacy and precipitation of opioid withdrawal Details Morphine Naloxone Nasal Spray Kloxxado Decreased opioid efficacy and precipitation of opioid withdrawal Details Morphine Neratinib Nerlynx Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Nifedipine Adalat® Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Palonosetron Injection Aloxi® Increased risk of serotonin syndrome Details

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