Morphine

73 interactions 6 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Morphine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Amitriptyline Elavil Explained Increased risk of urinary retention, severe constipation, paralytic ileus and an increased risk of serotonin syndrome Details Morphine Sertraline Explained Increased risk of serotonin syndrome Details Morphine Buprenorphine Belbuca Explained Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Morphine Trospium / Xanomeline Cobenfy Explained Increased morphine exposure, increased trospium exposure and an increased risk of urinary retention, constipation and paralytic il... Details Morphine Abrocitinib Cibinqo Explained Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Alvimopan Entereg Decreased opioid efficacy and precipitation of opioid withdrawal Details Morphine Aripiprazole Injection Abilify Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Asenapine Transdermal Patch Secuado Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Azithromycin AzaSite Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Atorvastatin Atorvaliq Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Aclidinium Oral Inhalation Tudorza Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Alogliptin Nesina Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Atropine Ophthalmic Atropine Care 1% Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Butorphanol Injection Butorphic Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Morphine Butorphanol Nasal Spray Stadol® NS Reduced analgesic effect or precipitation of withdrawal symptoms, and an increased risk of serotonin syndrome Details Morphine Canagliflozin Invokana Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Capmatinib Tabrecta Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Captopril Capoten® Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Morphine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Morphine Clopidogrel Plavix Reduced efficacy of clopidogrel Details Morphine Cyclopentolate Ophthalmic Akpentolate® Increased risk of urinary retention, severe constipation, and paralytic ileus Details Morphine Cyclosporine Injection Atopica Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Cyclosporine Ophthalmic Cequa Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Diazepam Nasal Spray Valtoco Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Diazepam Rectal Diastat Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Morphine Diphenhydramine Injection Banophen Increased risk of urinary retention, severe constipation, and paralytic ileus and an increased risk of profound sedation, respirat... Details Morphine Diphenhydramine Topical Afterbite with Antihistamine Increased risk of urinary retention, severe constipation, and paralytic ileus and an increased risk of profound sedation, respirat... Details Morphine Dolasetron Anzemet Increased risk of serotonin syndrome Details Morphine Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Morphine Elacestrant Orserdu Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Enasidenib Idhifa Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Entrectinib Rozlytrek Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Esketamine Nasal Spray Spravato Increased risk of sedation Details Morphine Felodipine Plendil® Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Morphine Fostamatinib Tavalisse Increased morphine exposure and an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profou... Details Morphine Furosemide Injection Disal Reduced efficacy of diuretics Details Morphine Glycopyrronium Topical Cuvposa® Increased risk of urinary retention, severe constipation, and paralytic ileus Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.