Nafcillin Injection

197 interactions 600 cited references
Also sold as: Unipen® Injection
About Nafcillin Injection

Nafcillin injection is used to treat infections caused by certain types of bacteria. Nafcillin injection is in a class of medications called penicillins. It works by killing bacteria. Antibiotics such as nafcillin injection will not work for colds, flu, or other viral infections. Taking antibiotics when they are not ne… Read the full Nafcillin Injection drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Nafcillin Injection Perampanel FYCOMPA Decreased plasma levels of perampanel Details Nafcillin Injection Pimavanserin Nuplazid Reduced pimavanserin exposure and reduced efficacy of pimavanserin Details Nafcillin Injection Piperaquine Reduced piperaquine exposure Details Nafcillin Injection Pirtobrutinib Jaypirca Reduced pirtobrutinib exposure and reduced efficacy of pirtobrutinib Details Nafcillin Injection Pralsetinib Gavreto Reduced pralsetinib exposure and reduced efficacy of pralsetinib Details Nafcillin Injection Praziquantel Biltricide Reduced praziquantel exposure and reduced efficacy of praziquantel Details Nafcillin Injection Pretomanid Decreased plasma levels of pretomanid Details Nafcillin Injection Quizartinib Vanflyta Reduced quizartinib exposure and reduced efficacy of quizartinib Details Nafcillin Injection Relacorilant Lifyorli Reduced relacorilant exposure and reduced efficacy of relacorilant Details Nafcillin Injection Remibrutinib Rhapsido Reduced remibrutinib exposure and reduced efficacy of remibrutinib Details Nafcillin Injection Repotrectinib Augtyro Reduced repotrectinib exposure and reduced efficacy of repotrectinib Details Nafcillin Injection Revumenib Revuforj Reduced revumenib exposure and reduced efficacy of revumenib or an increased risk of QT prolongation associated with the M1 metabo... Details Nafcillin Injection Rilzabrutinib Wayrilz Reduced rilzabrutinib exposure and reduced efficacy of rilzabrutinib Details Nafcillin Injection Rimegepant Nurtec Decreased exposure of rimegepant Details Nafcillin Injection Ripretinib Qinlock Decreased exposure of ripretinib and its active metabolite and reduction of antitumor activity Details Nafcillin Injection Rolitetracycline Decreased antibacterial effectiveness Details Nafcillin Injection Sarecycline Seysara Decreased antibacterial effectiveness Details Nafcillin Injection Sebetralstat Reduced sebetralstat exposure and reduced efficacy of sebetralstat Details Nafcillin Injection Segesterone Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Nafcillin Injection Selpercatinib Retevmo Reduced selpercatinib exposure and reduced anti-tumor activity Details Nafcillin Injection Selumetinib Koselugo Reduced selumetinib exposure and reduced efficacy of selumetinib Details Nafcillin Injection Sevabertinib Hyrnuo Reduced sevabertinib exposure and reduced efficacy of sevabertinib Details Nafcillin Injection Sildenafil Liqrev Reduced sildenafil exposure Details Nafcillin Injection Simeprevir Olysio® Decreased simeprevir exposure and loss of therapeutic effect Details Nafcillin Injection Sonrotoclax Reduced sonrotoclax exposure and reduced efficacy of sonrotoclax Details Nafcillin Injection Sufentanil Dsuvia Reduced SUFentanil exposure Details Nafcillin Injection Sunvozertinib Zegfrovy Reduced sunvozertinib exposure and reduced efficacy of sunvozertinib Details Nafcillin Injection Suzetrigine Journavx Reduced suzetrigine and M6-SUZ exposure and reduced efficacy of suzetrigine Details Nafcillin Injection Tacrolimus Astagraf Reduced tacrolimus exposure Details Nafcillin Injection Taletrectinib Ibtrozi Reduced taletrectinib exposure and reduced efficacy of taletrectinib Details Nafcillin Injection Tazemetostat Tazverik Reduced tazemetostat exposure and reduced efficacy of tazemetostat Details Nafcillin Injection Tetracycline Achromycin V® Decreased antibacterial effectiveness Details Nafcillin Injection Tezacaftor Reduced tezacaftor exposure and reduced efficacy of tezacaftor Details Nafcillin Injection Tigecycline Tygacil Decreased antibacterial effectiveness Details Nafcillin Injection Tramadol ConZip Reduced traMADol exposure, reduced efficacy of traMADol and an increased risk of seizure Details Nafcillin Injection Ubrogepant Ubrelvy Decreased ubrogepant exposure Details Nafcillin Injection Ulipristal Ella Reduced ulipristal exposure Details Nafcillin Injection Vanzacaftor Reduced vanzacaftor exposure and reduced efficacy of vanzacaftor Details Nafcillin Injection Velpatasvir Reduced velpatasvir plasma concentrations Details Nafcillin Injection Venetoclax Venclexta Reduced exposure to venetoclax and reduced venetoclax efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.