Nafcillin Injection

Name: Nafcillin Injection Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

197 interactions 600 cited references

Also sold as: Unipen® Injection

About Nafcillin Injection

Nafcillin injection is used to treat infections caused by certain types of bacteria. Nafcillin injection is in a class of medications called penicillins. It works by killing bacteria. Antibiotics such as nafcillin injection will not work for colds, flu, or other viral infections. Taking antibiotics when they are not ne… Read the full Nafcillin Injection drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lonafarnib Mavacamten Ranolazine Zoliflodacin Zuranolone Fruquintinib

4 Contraindicated 170 Major 13 Moderate 10 Minor

All (197) Contraindicated (4) Major (170) Moderate (13) Minor (10)

Contraindicated

Nafcillin Injection Lonafarnib Zokinvy Reduced lonafarnib exposure and reduced efficacy of lonafarnib Details Nafcillin Injection Mavacamten Camzyos Reduced mavacamten exposure and reduced efficacy of mavacamten Details Nafcillin Injection Ranolazine Aspruzyo Reduced ranolazine exposure Details Nafcillin Injection Zoliflodacin Reduced zoliflodacin exposure and reduced efficacy of zoliflodacin Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.