Nafcillin

66 interactions 3 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Entrectinib Doxorubicin Capmatinib Demeclocycline Estradiol Topical Medroxyprogesterone
55 Major 6 Moderate 5 Minor
All (66) Major (55) Moderate (6) Minor (5)

Major

Nafcillin Levonorgestrel After banger Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Nafcillin Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Nafcillin Lumateperone Caplyta Reduced lumateperone exposure Details Nafcillin Lurasidone Latuda Reduced lurasidone exposure Details Nafcillin Medroxyprogesterone Amen® Reduced medroxyPROGESTERone exposure Details Nafcillin Medroxyprogesterone Injection Depo-Provera Reduced medroxyPROGESTERone exposure Details Nafcillin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Nafcillin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Nafcillin Minocycline Amzeeq Decreased antibacterial effectiveness Details Nafcillin Minocycline Topical Amzeeq Decreased antibacterial effectiveness Details Nafcillin Mitapivat Aqvesme Reduced mitapivat exposure and reduced efficacy of mitapivat Details Nafcillin Neratinib Nerlynx Decreased exposure of neratinib and risk of reduced efficacy Details Nafcillin Nifedipine Adalat® Reduced NIFEdipine exposure Details Nafcillin Olaparib Lynparza Decreased olaparib exposure and efficacy Details Nafcillin Olutasidenib Rezlidhia Reduced olutasidenib exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.