Nafcillin
66 interactions 3 explained in plain English
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Entrectinib
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Demeclocycline
Estradiol Topical
Medroxyprogesterone
Major
Nafcillin Acetaminophen And Codeine Capital® & Codeine Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Nafcillin Buprenorphine Belbuca Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Nafcillin Atogepant Qulipta Reduced atogepant exposure Details Nafcillin Avapritinib Ayvakit Reduced avapritinib exposure and reduced efficacy of avapritinib Details Nafcillin Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Nafcillin Aficamten Reduced aficamten exposure and reduced efficacy of aficamten Details Nafcillin Amlodipine Amvaz® Reduced amLODIPine exposure Details Nafcillin Axitinib Inlyta Reduced axitinib exposure Details Nafcillin Bedaquiline Sirturo Reduced bedaquiline exposure and reduced efficacy of bedaquiline Details Nafcillin Brigatinib Alunbrig Decreased brigatinib exposure and efficacy Details Nafcillin Cabozantinib Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Nafcillin Cabozantinib (Thyroid Cancer) Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Nafcillin Capmatinib Tabrecta Decreased capmatinib exposure and reduction of antitumor activity Details Nafcillin Cyclosporine Injection Atopica Reduced cycloSPORINE exposure Details Nafcillin Cyclosporine Ophthalmic Cequa Reduced cycloSPORINE exposure Details Nafcillin Deflazacort Emflaza Decreased exposure to active metabolite of deflazacort Details Nafcillin Demeclocycline Declomycin® Decreased antibacterial effectiveness Details Nafcillin Doravirine Pifeltro Reduced doravirine exposure and reduced efficacy of doravirine Details Nafcillin Doxorubicin Adriamycin Reduced DOXOrubicin exposure Details Nafcillin Doxycycline Injection Acticlate Decreased antibacterial effectiveness Details Nafcillin Elacestrant Orserdu Reduced elacestrant exposure and reduced efficacy of elacestrant Details Nafcillin Encorafenib Braftovi Reduced encorafenib exposure and reduced efficacy of encorafenib Details Nafcillin Entrectinib Rozlytrek Reduced entrectinib exposure and reduced efficacy of entrectinib Details Nafcillin Eravacycline Injection Xerava Decreased antibacterial effectiveness Details Nafcillin Erdafitinib Balversa Reduced erdafitinib exposure Details Nafcillin Estradiol Delestrogen Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Nafcillin Estradiol Topical Divigel Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Nafcillin Estradiol Transdermal Patch Alora® Reduced hormonal contraceptive exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Nafcillin Exenatide Injection Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Nafcillin Fentanyl Transdermal Patch Duragesic® Reduced exposure of fentaNYL, reduced efficacy of fentaNYL and/or onset of opioid withdrawal symptoms Details Nafcillin Finerenone Kerendia Reduced finerenone exposure and reduced efficacy of finerenone Details Nafcillin Glasdegib Daurismo Reduced glasdegib exposure Details Nafcillin Hydroxychloroquine Plaquenil An increased risk of seizures Details Nafcillin Ibrexafungerp Brexafemme Decreased ibrexafungerp plasma concentrations Details Nafcillin Infigratinib Truseltiq Decreased infigratinib plasma concentrations Details Nafcillin Lefamulin Xenleta Reduced lefamulin exposure and reduced efficacy of lefamulin Details Nafcillin Lenacapavir Injection Sunlenca Reduced lenacapavir exposure which may result in the loss of therapeutic effect and development of resistance to lenacapavir Details Nafcillin Lenacapavir Oral Sunlenca Reduced lenacapavir exposure which may result in the loss of therapeutic effect and development of resistance to lenacapavir Details Nafcillin Leniolisib Joenja Reduced leniolisib exposure and reduced efficacy of leniolisib Details Nafcillin Letermovir Injection Prevymis Reduced letermovir exposure and reduced efficacy of letermovir DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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