Naloxone Nasal Spray

Name: Naloxone Nasal Spray Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

6 interactions 184 cited references

Also sold as: Kloxxado Kloxxado® Narcan Narcan® Rextovy Rezenopy

About Naloxone Nasal Spray

Naloxone nasal spray is used along with emergency medical treatment to reverse the life-threatening effects of a known or suspected opiate (narcotic) overdose in adults and children. Naloxone nasal spray is in a class of medications called opiate antagonists. It works by blocking the effects of opiates to relieve dange… Read the full Naloxone Nasal Spray drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Morphine Morphine Sulfate Liposome Naldemedine Naloxegol

4 Major 2 Moderate

All (6) Major (4) Moderate (2)

Moderate

Naloxone Nasal Spray Clonidine Duraclon Hypertension Details Naloxone Nasal Spray Yohimbine Increased adverse effects Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.