Nateglinide

209 interactions 492 cited references
Also sold as: Starlix®
About Nateglinide

Nateglinide is used alone or in combination with other medications to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood) in people whose diabetes cannot be controlled by diet and exercise alone. Nateglinide belongs to a class o… Read the full Nateglinide drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ensitrelvir Abiraterone Acetate Insulin Glulisine (Rdna Origin) Injection Chloroquine Ofloxacin Otic Letermovir Injection
1 Contraindicated 95 Major 112 Moderate 1 Minor
All (209) Contraindicated (1) Major (95) Moderate (112) Minor (1)

Major

Nateglinide Semaglutide Ozempic An increased risk of hypoglycemia Details Nateglinide Simeprevir Olysio® Increased exposure of nateglinide Details Nateglinide Somatrogon-Ghla Reduced insulin sensitivity Details Nateglinide Sparfloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Nateglinide Tazemetostat Tazverik Reduced CYP3A substrate exposure and reduced efficacy of CYP3A substrate Details Nateglinide Tegafur Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Nateglinide Thioctic Acid Increased risk of hypoglycemia Details Nateglinide Triamterene Dyrenium An increased risk of hyperglycemia and an increased insulin requirement Details Nateglinide Trovafloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Nateglinide Voclosporin Lupkynis Increased OATP1B1 substrate exposure Details Nateglinide Voriconazole Vfend Increased CYP3A4/CYP2C9 substrate exposure and an increased of CYP3A4/CYP2C9 substrates-related adverse effects Details Nateglinide Octreotide Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Nateglinide Octreotide Injection Bynfezia An increased risk of hypoglycemia and impaired glucose regulation Details Nateglinide Ofloxacin Ophthalmic Ocuflox Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Nateglinide Ofloxacin Otic Floxin® Otic Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.