Nateglinide

209 interactions 492 cited references

Also sold as: Starlix®

About Nateglinide

Nateglinide is used alone or in combination with other medications to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood) in people whose diabetes cannot be controlled by diet and exercise alone. Nateglinide belongs to a class o… Read the full Nateglinide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ensitrelvir Abiraterone Acetate Insulin Glulisine (Rdna Origin) Injection Chloroquine Ofloxacin Otic Letermovir Injection

1 Contraindicated 95 Major 112 Moderate 1 Minor

All (209) Contraindicated (1) Major (95) Moderate (112) Minor (1)

Moderate

Nateglinide Lisinopril Prinivil An increased risk of hypoglycemia Details Nateglinide Aspirin Acuprin® Increased risk of hypoglycemia Details Nateglinide Aspirin Rectal Aspirin Increased risk of hypoglycemia Details Nateglinide Atenolol Tenormin Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nateglinide Acebutolol Sectral® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nateglinide Benazepril Lotensin An increased risk of hypoglycemia Details Nateglinide Alogliptin Nesina An increased risk of hypoglycemia Details Nateglinide Betaxolol Betoptic S Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nateglinide Betaxolol Ophthalmic Betoptic® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nateglinide Bisoprolol Zebeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nateglinide Captopril Capoten® An increased risk of hypoglycemia Details Nateglinide Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) An increased risk of hypoglycemia Details Nateglinide Enalapril Epaned An increased risk of hypoglycemia Details Nateglinide Encorafenib Braftovi Increased OATP1B1 substrate exposure and increased risk of OATP1B1 substrate-related toxicities Details Nateglinide Esmolol Brevibloc Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nateglinide Exenatide Injection Bydureon Increased risk of hypoglycemia Details Nateglinide Fosinopril Monopril® An increased risk of hypoglycemia Details Nateglinide Labetalol Normodyne® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nateglinide Levobunolol Ophthalmic AKBeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nateglinide Levothyroxine Ermeza Worsening of glycemic control Details Nateglinide Linagliptin Tradjenta An increased risk of hypoglycemia Details Nateglinide Linezolid Injection Zyvox An increased risk of hypoglycemia Details Nateglinide Liraglutide Injection Saxenda An increased risk of hypoglycemia Details Nateglinide Metformin Fortamet® An increased risk of hypoglycemia Details Nateglinide Miconazole Buccal Oravig Increased risk of hypoglycemia Details Nateglinide Miconazole Topical Aloe Vesta Antifungal Increased risk of hypoglycemia Details Nateglinide Miconazole Vaginal Lagicam Increased risk of hypoglycemia Details Nateglinide Miconazole Aloe Vesta Antifungal Increased risk of hypoglycemia Details Nateglinide Moexipril Univasc® An increased risk of hypoglycemia Details Nateglinide Nadolol Corgard Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nateglinide Amiodarone Nexterone Increased risk of hypoglycemia Details Nateglinide Amprenavir Worsening glycemic control Details Nateglinide Artemether Reduced CYP3A4 substrate exposure and reduced efficacy of CYP3A4 substrate Details Nateglinide Atazanavir Reyataz Worsening glycemic control Details Nateglinide Bexagliflozin An increased risk of hypoglycemia Details Nateglinide Bitter Melon Increased risk of hypoglycemia Details Nateglinide Carteolol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nateglinide Carvedilol Coreg Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nateglinide Celiprolol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nateglinide Clarithromycin Biaxin Increased nateglinide exposure and an increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.