Nebivolol

220 interactions 1 explained in plain English 373 cited references

Also sold as: Bystolic Bystolic®

About Nebivolol

Nebivolol is a beta blocker used to treat high blood pressure, either alone or combined with other medications. Read the full Nebivolol drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mavorixafor Cinacalcet Clonidine Olodaterol Oral Inhalation Indacaterol Oral Inhalation Bupropion

1 Contraindicated 59 Major 160 Moderate

All (220) Contraindicated (1) Major (59) Moderate (160)

Moderate

Nebivolol Acarbose Prandase® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Nebivolol Aspirin Acuprin® Reduced antihypertensive effect Details Nebivolol Aspirin Rectal Aspirin Reduced antihypertensive effect Details Nebivolol Alfuzosin UroXatral An exaggerated hypotensive response to the first dose of the alpha blocker Details Nebivolol Alogliptin Nesina Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Bromfenac Ophthalmic Bromday® Reduced antihypertensive effect Details Nebivolol Canagliflozin Invokana Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Dapagliflozin Farxiga Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Diclofenac Ophthalmic Voltaren® Eye Drops Reduced antihypertensive effect Details Nebivolol Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced antihypertensive effect Details Nebivolol Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced antihypertensive effect Details Nebivolol Diclofenac Transdermal Patch Flector Reduced antihypertensive effect Details Nebivolol Digoxin Cardoxin® Increased risk of bradycardia and possible digitalis glycoside toxicity Details Nebivolol Disopyramide Norpace Bradycardia and decreased cardiac output Details Nebivolol Dobutamine Reversal of the beta-blocking effects of nebivolol and, potentially, severe hypotension Details Nebivolol Doxazosin Cardura An exaggerated hypotensive response to the first dose of the alpha blocker Details Nebivolol Dulaglutide Injection Trulicity Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Ertugliflozin Steglatro Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Etodolac Lodine Reduced antihypertensive effect Details Nebivolol Exenatide Injection Bydureon Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Fenoprofen Fenopron Reduced antihypertensive effect Details Nebivolol Flurbiprofen Ansaid Reduced antihypertensive effect Details Nebivolol Flurbiprofen Ophthalmic Ocufen Reduced antihypertensive effect Details Nebivolol Glimepiride Amaryl Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Glipizide Glucotrol Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Glucagon Injection Baqsimi A transient increase in pulse and blood pressure Details Nebivolol Glucagon Injection / Solution Baqsimi A transient increase in pulse and blood pressure Details Nebivolol Glucagon Nasal Powder Baqsimi A transient increase in pulse and blood pressure Details Nebivolol Ibuprofen Addaprin Reduced antihypertensive effect Details Nebivolol Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Insulin Detemir (Rdna Origin) Injection Levemir Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Insulin Glulisine (Rdna Origin) Injection Apidra Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Ketoprofen Actron® Reduced antihypertensive effect Details Nebivolol Ketorolac Acular Reduced antihypertensive effect Details Nebivolol Ketorolac Injection Acular Reduced antihypertensive effect Details Nebivolol Ketorolac Nasal Spray Sprix Reduced antihypertensive effect Details Nebivolol Ketorolac Ophthalmic Acular Reduced antihypertensive effect Details Nebivolol Linagliptin Tradjenta Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.