Nebivolol

220 interactions 1 explained in plain English 373 cited references
Also sold as: Bystolic Bystolic®
About Nebivolol

Nebivolol is a beta blocker used to treat high blood pressure, either alone or combined with other medications. Read the full Nebivolol drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Nebivolol Sertraline Increased exposure to nebivolol Details Nebivolol Albuterol Oral Inhalation Accuneb® Explained Reduced efficacy of albuterol Details Nebivolol Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Nebivolol Clonidine Transdermal Patch Catapres An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Nebivolol Indacaterol Oral Inhalation Arcapta® Decreased efficacy of indacaterol Details Nebivolol Lacosamide Injection Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Nebivolol Methylergonovine Methergine An increased risk of enhanced vasoconstrictive Details Nebivolol Abiraterone Acetate Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Nebivolol Abiraterone Acetate, Micronized Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Nebivolol Albuterol ProAir Reduced efficacy of albuterol Details Nebivolol Bupropion Aplenzin Increased exposure to nebivolol Details Nebivolol Ceritinib Zykadia Increased risk of bradycardia Details Nebivolol Cinacalcet Increased exposure to nebivolol Details Nebivolol Clonidine Duraclon An increased risk of worsen sinus node dysfunction and atrioventricular node conduction, an increased risk of bradycardia and AV b... Details Nebivolol Cobicistat Tybost Increased beta blocker exposure and an increased risk of beta blocker-related adverse effects Details Nebivolol Crizotinib Xalkori An increased risk of bradycardia Details Nebivolol Darunavir Increased beta blocker exposure and an increased risk of beta blocker-related adverse effects Details Nebivolol Desvenlafaxine Pristiq Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse events Details Nebivolol Diltiazem Cardizem An increased risk of hypotension, bradycardia and slow AV conduction Details Nebivolol Doxepin Prudoxin Increased exposure to nebivolol Details Nebivolol Dronedarone Multaq Increased exposure to some beta blockers and increased incidence of bradycardia Details Nebivolol Duloxetine Increased exposure to nebivolol Details Nebivolol Epinephrine Antagonized cardio stimulating and bronchodilation effects of EPINEPHrine, an increased risk of severe hypertension and an increas... Details Nebivolol Escitalopram Lexapro Increased CYP2D6 substrate exposure Details Nebivolol Fedratinib Inrebic Increased CYP2D6 substrate exposure Details Nebivolol Fenoldopam Exaggeration of hypotensive response Details Nebivolol Fexinidazole Increased risk of bradycardia Details Nebivolol Fingolimod Gilenya Slowing of the heart rate or atrioventricular conduction, which may result in severe bradycardia or heart block Details Nebivolol Fluoxetine RECONCILE Increased exposure to nebivolol Details Nebivolol Formoterol Perforomist Reduced efficacy of formoterol or reduced efficacy of beta-adrenergic blocker Details Nebivolol Givosiran Increased plasma concentration of CYP2D6 substrates Details Nebivolol Indacaterol Decreased efficacy of indacaterol Details Nebivolol Insulin Afrezza Increased or reduced blood glucose lowering effect of insulin and reduced symptoms of hypoglycemia Details Nebivolol Insulin Icodec-Abae Awiqli An increased risk of hypoglycemia, which may sometimes be followed by hyperglycemia and an increased risk of blunted recognition o... Details Nebivolol Iohexol Lower threshold for contrast reactions, increased risk of more severe contrast reaction, reduced efficacy when treating hypersensi... Details Nebivolol Lacosamide Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Nebivolol Landiolol An increased risk of myocardial contractility depression and increase the risk of bradycardia or heart block Details Nebivolol Levalbuterol Xopenex Reduced efficacy of levalbuterol Details Nebivolol Lumefantrine Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse reactions Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.