Nebivolol

220 interactions 1 explained in plain English 373 cited references
Also sold as: Bystolic Bystolic®
About Nebivolol

Nebivolol is a beta blocker used to treat high blood pressure, either alone or combined with other medications. Read the full Nebivolol drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mavorixafor Cinacalcet Clonidine Olodaterol Oral Inhalation Indacaterol Oral Inhalation Bupropion
1 Contraindicated 59 Major 160 Moderate
All (220) Contraindicated (1) Major (59) Moderate (160)

Major

Nebivolol Moclobemide Increased exposure to nebivolol Details Nebivolol Olodaterol Striverdi Reduced olodaterol exposure and reduced beta-adrenergic blockers exposure Details Nebivolol Panobinostat Farydak Increased CYP2D6 substrate exposure Details Nebivolol Paroxetine Paxil Increased exposure to nebivolol Details Nebivolol Phenelzine Nardil An increased risk of exaggerated hypotensive effect and an increased risk of bradycardia Details Nebivolol Ponesimod Ponvory An increased risk of severe bradycardia and heart block Details Nebivolol Quinidine Cardioquin® Increased exposure to nebivolol Details Nebivolol Quinine Increased exposure to nebivolol Details Nebivolol Ranolazine Aspruzyo Increased CYP2D6 substrates exposure Details Nebivolol Rivastigmine Exelon Additive bradycardic effects Details Nebivolol Rolapitant Varubi Increased exposure to nebivolol Details Nebivolol Salmeterol Serevent Reduced efficacy of salmeterol Details Nebivolol Siponimod Mayzent An increased risk of severe bradycardia and heart block Details Nebivolol Terbinafine Lamisil Increased exposure to nebivolol Details Nebivolol Terbutaline Brethine® Reduced efficacy of terbutaline Details Nebivolol Venlafaxine Increased CYP2D6 substrate exposure and an increased risk of associated toxicity Details Nebivolol Verapamil Calan An increased risk of hypotension, bradycardia and slow AV conduction Details Nebivolol Vilanterol Decreased efficacy of vilanterol Details Nebivolol Olodaterol Oral Inhalation Striverdi Reduced olodaterol exposure and reduced beta-adrenergic blockers exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.