Nebivolol

220 interactions 1 explained in plain English 373 cited references
Also sold as: Bystolic Bystolic®
About Nebivolol

Nebivolol is a beta blocker used to treat high blood pressure, either alone or combined with other medications. Read the full Nebivolol drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mavorixafor Cinacalcet Clonidine Olodaterol Oral Inhalation Indacaterol Oral Inhalation Bupropion
1 Contraindicated 59 Major 160 Moderate
All (220) Contraindicated (1) Major (59) Moderate (160)

Moderate

Nebivolol Etrasimod Velsipity May increase the risk of transient decrease in heart rate Details Nebivolol Exenatide Bydureon Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Felbinac Reduced antihypertensive effect Details Nebivolol Fepradinol Reduced antihypertensive effect Details Nebivolol Feprazone Reduced antihypertensive effect Details Nebivolol Floctafenine Reduced antihypertensive effect Details Nebivolol Flufenamic Acid Reduced antihypertensive effect Details Nebivolol Glucagon A transient increase in pulse and blood pressure Details Nebivolol Glyburide DiaBeta® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Indomethacin Indocin Reduced antihypertensive effect Details Nebivolol Insulin Aspart, Recombinant Fiasp Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Insulin Degludec Tresiba Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Insulin Detemir Levemir Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Insulin Glargine, Recombinant Basaglar Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Insulin Glulisine Apidra Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Insulin Human Inhaled Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Insulin Human Isophane (Nph) Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Insulin Human Regular Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Insulin Lispro, Recombinant Admelog Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Isoproterenol Reversal of the beta-blocking effects of nebivolol and, potentially, severe hypotension Details Nebivolol Lidoflazine Hypotension, bradycardia, and AV conduction disturbances Details Nebivolol Liraglutide Saxenda Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Lixisenatide Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Lornoxicam Reduced antihypertensive effect Details Nebivolol Loxoprofen Reduced antihypertensive effect Details Nebivolol Lumiracoxib Reduced antihypertensive effect Details Nebivolol Ma Huang Reduced hypotensive effect of beta-adrenergic blockers Details Nebivolol Methacholine Impaired reversal of methacholine-caused bronchoconstriction Details Nebivolol Metildigoxin Increased risk of bradycardia and possible digitalis glycoside toxicity Details Nebivolol Morniflumate Reduced antihypertensive effect Details Nebivolol Moxisylyte An exaggerated hypotensive response to the first dose of the alpha blocker Details Nebivolol Moxonidine Rebound hypertension Details Nebivolol Nepafenac Ilevro Reduced antihypertensive effect Details Nebivolol Nifedipine Adalat® An increased risk of congestive heart failure, severe hypotension or exacerbation of angina Details Nebivolol Niflumic Acid Reduced antihypertensive effect Details Nebivolol Nimesulide Reduced antihypertensive effect Details Nebivolol Nimesulide Beta Cyclodextrin Reduced antihypertensive effect Details Nebivolol Oxaprozin Coxanto Reduced antihypertensive effect Details Nebivolol Oxyphenbutazone Reduced antihypertensive effect Details Nebivolol Paltusotine Palsonify An increased risk of PR interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.