Nebivolol

220 interactions 1 explained in plain English 373 cited references
Also sold as: Bystolic Bystolic®
About Nebivolol

Nebivolol is a beta blocker used to treat high blood pressure, either alone or combined with other medications. Read the full Nebivolol drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Mavorixafor Cinacalcet Clonidine Olodaterol Oral Inhalation Indacaterol Oral Inhalation Bupropion
1 Contraindicated 59 Major 160 Moderate
All (220) Contraindicated (1) Major (59) Moderate (160)

Moderate

Nebivolol Parecoxib Reduced antihypertensive effect Details Nebivolol Patiromer Veltassa Reduced nebivolol exposure and reduced efficacy of nebivolol Details Nebivolol Phenoxybenzamine Dibenzyline An exaggerated hypotensive response to the first dose of the alpha blocker Details Nebivolol Phentolamine An exaggerated hypotensive response to the first dose of the alpha blocker Details Nebivolol Phenylbutazone Equi-Phar Reduced antihypertensive effect Details Nebivolol Piketoprofen Reduced antihypertensive effect Details Nebivolol Pioglitazone Actos Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Piroxicam Feldene Reduced antihypertensive effect Details Nebivolol Pramlintide Symlin Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Pranoprofen Reduced antihypertensive effect Details Nebivolol Prazosin Minipress An exaggerated hypotensive response to the first dose of the alpha blocker Details Nebivolol Proglumetacin Reduced antihypertensive effect Details Nebivolol Propafenone Rythmol Increased nebivolol exposure and plasma levels Details Nebivolol Propyphenazone Reduced antihypertensive effect Details Nebivolol Proquazone Reduced antihypertensive effect Details Nebivolol Repaglinide Prandin® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Rofecoxib Reduced antihypertensive effect Details Nebivolol Rosiglitazone Avandia® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Salicylic Acid Reduced antihypertensive effect Details Nebivolol Salsalate Disalcid Reduced antihypertensive effect Details Nebivolol Saxagliptin Onglyza Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Sildenafil Liqrev Decreased sildenafil exposure and plasma levels and increased risk of hypotension Details Nebivolol Sitagliptin Brynovin Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Sodium Salicylate Reduced antihypertensive effect Details Nebivolol Sulindac Clinoril® Reduced antihypertensive effect Details Nebivolol Tamsulosin Flomax An exaggerated hypotensive response to the first dose of the alpha blocker Details Nebivolol Tenoxicam Reduced antihypertensive effect Details Nebivolol Terazosin Hytrin® An exaggerated hypotensive response to the first dose of the alpha blocker Details Nebivolol Tiaprofenic Acid Reduced antihypertensive effect Details Nebivolol Tolazamide Tolinase® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Tolbutamide Orinase® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Tolfenamic Acid Reduced antihypertensive effect Details Nebivolol Tolmetin Tolectin 600 Reduced antihypertensive effect Details Nebivolol Tranylcypromine Parnate An increased risk of more pronounced bradycardia and postural hypotension Details Nebivolol Trimazosin An exaggerated hypotensive response to the first dose of the alpha blocker Details Nebivolol Urapidil An exaggerated hypotensive response to the first dose of the alpha blocker Details Nebivolol Valdecoxib Reduced antihypertensive effect Details Nebivolol Vildagliptin Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Nebivolol Yohimbine Reduced beta-adrenergic blocker effectiveness Details Nebivolol Zileuton Zyflo A significant increase in beta-adrenergic blockade Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.