Neomycin

19 interactions
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Furosemide Injection Aspirin Rectal Foscarnet Injection Cidofovir Injection Colistimethate Injection Digoxin
11 Major 2 Moderate 6 Minor
All (19) Major (11) Moderate (2) Minor (6)

Major

Neomycin Aspirin Acuprin® Increased aspirin exposure and an increased risk of nephrotoxicity Details Neomycin Aspirin Rectal Aspirin Increased aspirin exposure and an increased risk of nephrotoxicity Details Neomycin Cefepime Injection Maxipime® An increased risk of nephrotoxicity and an increased risk of ototoxicity Details Neomycin Cidofovir Injection Vistide® Nephrotoxicity Details Neomycin Colistimethate Injection Coly-Mycin M® Respiratory depression Details Neomycin Digoxin Cardoxin® Reduced digoxin exposure Details Neomycin Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Neomycin Foscarnet Injection Foscavir Nephrotoxicity Details Neomycin Furosemide Injection Disal Increased neomycin exposure, an increased risk of neomycin toxicity and additive ototoxicity and/or nephrotoxicity Details Neomycin Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Neomycin Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Moderate

Neomycin Cyclosporine Injection Atopica Renal dysfunction or nephrotoxicity Details Neomycin Cyclosporine Ophthalmic Cequa Renal dysfunction or nephrotoxicity Details

Minor

Neomycin Amoxicillin Amoxi Drop Loss of aminoglycoside efficacy Details Neomycin Ampicillin Amcill® Loss of aminoglycoside efficacy Details Neomycin Ampicillin Injection Omnipen-N® Loss of aminoglycoside efficacy Details Neomycin Nafcillin Injection Unipen® Injection Loss of aminoglycoside efficacy Details Neomycin Penicillin G Procaine Injection Bactracillin G Loss of aminoglycoside efficacy Details Neomycin Penicillin V Potassium Beepen-VK® Loss of aminoglycoside efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.