Nepafenac

91 interactions 5 explained in plain English
Also sold as: Ilevro Nevanac
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Nepafenac Amitriptyline Elavil Explained An increased risk of bleeding Details Nepafenac Sertraline Explained An increased risk of bleeding Details Nepafenac Apixaban Eliquis Explained An increased risk of bleeding Details Nepafenac Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Nepafenac Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Nepafenac Betrixaban Bevyxxa® An increased risk of bleeding Details Nepafenac Anagrelide Agrylin An increased risk of bleeding Details Nepafenac Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Nepafenac Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Nepafenac Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Nepafenac Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Nepafenac Clopidogrel Plavix An increased risk of bleeding Details Nepafenac Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Nepafenac Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Nepafenac Dabigatran Pradaxa® An increased risk of bleeding Details Nepafenac Dabigatran Etexilate An increased risk of bleeding Details Nepafenac Dalteparin Injection Fragmin An increased risk of bleeding Details Nepafenac Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Nepafenac Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Nepafenac Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Nepafenac Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Nepafenac Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Nepafenac Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Nepafenac Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Nepafenac Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Nepafenac Dipyridamole Permole® An increased risk of bleeding Details Nepafenac Edoxaban Savaysa An increased risk of bleeding Details Nepafenac Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Nepafenac Enoxaparin Lovenox An increased risk of bleeding Details Nepafenac Enoxaparin Injection Lovenox An increased risk of bleeding Details Nepafenac Epoprostenol Flolan An increased risk of bleeding Details Nepafenac Etodolac Lodine Increased risk of bleeding Details Nepafenac Fenoprofen Fenopron Increased risk of bleeding Details Nepafenac Flurbiprofen Ansaid Increased risk of bleeding Details Nepafenac Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details Nepafenac Fondaparinux Arixtra An increased risk of bleeding Details Nepafenac Fondaparinux Injection Arixtra An increased risk of bleeding Details Nepafenac Furosemide Injection Disal Reduced diuretic effectiveness and possible nephrotoxicity Details Nepafenac Heparin An increased risk of bleeding Details Nepafenac Heparin Injection Lipo-Hepin® An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.