Nepafenac

91 interactions 5 explained in plain English

Also sold as: Ilevro Nevanac

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ketorolac Ophthalmic Diclofenac Ophthalmic Epoprostenol

4 Contraindicated 59 Major 28 Moderate

All (91) Contraindicated (4) Major (59) Moderate (28)

Moderate

Nepafenac Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Nepafenac Atenolol Tenormin Explained Reduced antihypertensive effect Details Nepafenac Acebutolol Sectral® Reduced antihypertensive effect Details Nepafenac Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Nepafenac Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Nepafenac Betaxolol Betoptic S Reduced antihypertensive effect Details Nepafenac Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Nepafenac Bisoprolol Zebeta® Reduced antihypertensive effect Details Nepafenac Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Nepafenac Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Nepafenac Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Nepafenac Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Nepafenac Esmolol Brevibloc Reduced antihypertensive effect Details Nepafenac Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Nepafenac Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Nepafenac Labetalol Normodyne® Reduced antihypertensive effect Details Nepafenac Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Nepafenac Levofloxacin Levaquin An increased risk of seizures Details Nepafenac Levofloxacin Injection Levaquin An increased risk of seizures Details Nepafenac Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Nepafenac Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Nepafenac Nadolol Corgard Reduced antihypertensive effect Details Nepafenac Nebivolol Bystolic Reduced antihypertensive effect Details Nepafenac Ofloxacin Floxin® An increased risk of seizures Details Nepafenac Ofloxacin Ophthalmic Ocuflox An increased risk of seizures Details Nepafenac Ofloxacin Otic Floxin® Otic An increased risk of seizures Details Nepafenac Penbutolol Levatol® Reduced antihypertensive effect Details Nepafenac Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.