Nepafenac

91 interactions 5 explained in plain English
Also sold as: Ilevro Nevanac
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Injection Ketorolac Nasal Spray Ketorolac Ketorolac Ophthalmic Diclofenac Ophthalmic Epoprostenol
4 Contraindicated 59 Major 28 Moderate
All (91) Contraindicated (4) Major (59) Moderate (28)

Major

Nepafenac Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Nepafenac Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Nepafenac Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Nepafenac Iloprost Aurlumyn An increased risk of bleeding Details Nepafenac Ketoprofen Actron® Increased risk of bleeding Details Nepafenac Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Nepafenac Meclofenamate Meclodium® Increased risk of bleeding Details Nepafenac Mefenamic Acid Ponstel® Increased risk of bleeding Details Nepafenac Meloxicam Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Nepafenac Meloxicam Injection Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Nepafenac Melphalan Alkeran An increased risk of bleeding Details Nepafenac Melphalan Injection Alkeran An increased risk of bleeding Details Nepafenac Mesalamine Apriso Increased risk of bleeding Details Nepafenac Mesalamine Rectal Canasa Increased risk of bleeding Details Nepafenac Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Nepafenac Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Nepafenac Nabumetone Relafen Increased risk of bleeding Details Nepafenac Naproxen Aleve Increased risk of bleeding Details Nepafenac Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.