Nilotinib and Cyclosporine Injection: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Nilotinib
No brand names on recordCyclosporine Injection
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased exposure of cycloSPORINE and nilotinib
Interaction Deep Dive
Use caution when coadministering nilotinib (a moderate CYP3A4 inhibitor and P-glycoprotein [P-gp] substrate) with cycloSPORINE (CYP3A4 substrate and P-gp inhibitor), as it may result in an increased exposure of both drugs. Dose adjustment of cycloSPORINE may be required1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated cycloSPORINE metabolism by nilotinib; inhibition of P-glycoprotein-mediated transport of nilotinib by cycloSPORINE
Literature reports
1 report — tap to read
a) In patients with chronic myeloid leukemia, a 2.6-fold increase in the systemic exposure of oral midazolam (a CYP3A4 substrate) was reported with multiple doses of nilotinib 1.
Common questions
Can I take Nilotinib and Cyclosporine Injection together?
Increased exposure of cycloSPORINE and nilotinib Always confirm with your pharmacist or prescriber before making any change.
How serious is the Nilotinib and Cyclosporine Injection interaction?
It is rated moderate. Can be significant — usually manageable with monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.
Questions for your pharmacist
- Does my dose of Nilotinib or Cyclosporine Injection need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there anything you'd monitor while I'm on both?
References (1)
- Product Information: TASIGNA(R) oral capsules, nilotinib oral capsules. Novartis Pharmaceuticals Corporation (per FDA), East Hanover, NJ, 2014. DailyMed
Keep reading about Nilotinib
Keep reading about Cyclosporine Injection
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