Nilutamide

Name: Nilutamide Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

24 interactions 74 cited references

Also sold as: Nilandron Nilandron®

About Nilutamide

Nilutamide is used after surgery to treat prostate cancer. Nilutamide is in a class of medications called antiandrogens. It works by blocking the effect of androgen (a male hormone), to stop the growth and spread of cancer cells. Read the full Nilutamide drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Smallpox Monkeypox Vaccine Yellow Fever Vaccine Measles Virus Vaccine, Live Dengue Tetravalent Vaccine, Live Rubella Virus Vaccine, Live Mumps Virus Vaccine, Live

9 Contraindicated 11 Major 4 Moderate

All (24) Contraindicated (9) Major (11) Moderate (4)

Major

Nilutamide Azathioprine Azasan An increased risk of hepatotoxicity Details Nilutamide Mercaptopurine Purinethol® An increased risk of hepatotoxicity Details Nilutamide Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Nilutamide Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Nilutamide Adenovirus Vaccine Type 4, Live An increased risk of infection by the live vaccine Details Nilutamide Adenovirus Vaccine Type 7, Live An increased risk of infection by the live vaccine Details Nilutamide Cholera Vaccine Ipol An increased risk of infection by the live vaccine Details Nilutamide Ebola Zaire Vaccine, Live An increased risk of infection by the live vaccine Details Nilutamide Influenza Virus Vaccine, Live An increased risk of infection by the live vaccine Details Nilutamide Levoketoconazole Recorlev Increased risk of serious hepatotoxicity and drug-induced liver injury Details Nilutamide Rotavirus Vaccine, Live An increased risk of infection by the live vaccine Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.