Ofloxacin Ophthalmic

337 interactions 674 cited references

Also sold as: Ocuflox Ocuflox®

About Ofloxacin Ophthalmic

Ophthalmic ofloxacin ophthalmic is used to treat bacterial infections of the eye, including conjunctivitis (pink eye) and ulcers of the cornea. Ofloxacin is in a class of medications called quinolone antibiotics. It works by killing bacterial cells that cause infection. Read the full Ofloxacin Ophthalmic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levoketoconazole Mesoridazine Pimozide Piperaquine Saquinavir Bepridil

12 Contraindicated 240 Major 84 Moderate 1 Minor

All (337) Contraindicated (12) Major (240) Moderate (84) Minor (1)

Major

Ofloxacin Ophthalmic Canagliflozin Invokana Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Ceritinib Zykadia An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Chloroquine Aralen® An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Chlorpromazine An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Chlorpropamide Diabinese® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Ofloxacin Ophthalmic Ciprofloxacin An increased risk of fluoroquinolones-related adverse reactions and an increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Citalopram Celexa An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Clarithromycin Biaxin An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Clofazimine An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Clomipramine Anafranil An increased risk of QT interval prolongation and an increased risk of seizures Details Ofloxacin Ophthalmic Clothiapine Increased risk of cardiac arrhythmias Details Ofloxacin Ophthalmic Clozapine Clozaril Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Corticotropin An increased risk of tendon rupture Details Ofloxacin Ophthalmic Cortisone An increased risk of tendon rupture Details Ofloxacin Ophthalmic Cosyntropin An increased risk of tendon rupture Details Ofloxacin Ophthalmic Crizotinib Xalkori An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Cyclobenzaprine Amrix An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Dabrafenib Tafinlar An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Dapagliflozin Farxiga Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Dasatinib Phyrago An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Deflazacort Emflaza An increased risk of tendon rupture Details Ofloxacin Ophthalmic Degarelix Firmagon Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Delamanid Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Desflurane Suprane An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Desipramine Norpramin An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Dexamethasone An increased risk of tendon rupture Details Ofloxacin Ophthalmic Dexmedetomidine Dexased Increased risk of cardiac arrhythmias Details Ofloxacin Ophthalmic Disopyramide Norpace An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Dofetilide Tikosyn An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Ophthalmic Dolasetron Anzemet An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Domperidone Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Donepezil Adlarity Increased risk of QT-interval prolongation and torsade de pointes Details Ofloxacin Ophthalmic Dordaviprone An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Doxepin Prudoxin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Ophthalmic Droperidol An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Dulaglutide Trulicity Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Efavirenz An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.