Ofloxacin Ophthalmic

337 interactions 674 cited references

Also sold as: Ocuflox Ocuflox®

About Ofloxacin Ophthalmic

Ophthalmic ofloxacin ophthalmic is used to treat bacterial infections of the eye, including conjunctivitis (pink eye) and ulcers of the cornea. Ofloxacin is in a class of medications called quinolone antibiotics. It works by killing bacterial cells that cause infection. Read the full Ofloxacin Ophthalmic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levoketoconazole Mesoridazine Pimozide Piperaquine Saquinavir Bepridil

12 Contraindicated 240 Major 84 Moderate 1 Minor

All (337) Contraindicated (12) Major (240) Moderate (84) Minor (1)

Major

Ofloxacin Ophthalmic Acarbose Prandase® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Acecainide An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Ophthalmic Adagrasib Krazati An increased risk of QT interval prolongation, torsade de pointes, polymorphic ventricular tachycardia, other serious arrhythmias Details Ofloxacin Ophthalmic Albiglutide Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Alfuzosin UroXatral An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Alogliptin Nesina Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Alosetron Increased plasma concentration and half-life of alosetron Details Ofloxacin Ophthalmic Amiodarone Nexterone An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Ophthalmic Amisulpride Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Ofloxacin Ophthalmic Amitriptyline Elavil An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Amoxapine An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Anagrelide Agrylin Increased anagrelide exposure and increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Apomorphine Apokyn An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Aripiprazole Abilify An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Aripiprazole Lauroxil Aristada An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Artemether An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Asenapine Saphris Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Astemizole An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Atazanavir Reyataz An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Azimilide An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Ophthalmic Azithromycin AzaSite An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Bedaquiline Sirturo Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Betamethasone Betavet An increased risk of tendon rupture Details Ofloxacin Ophthalmic Bretylium An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Ophthalmic Budesonide Entocort An increased risk of tendon rupture Details Ofloxacin Ophthalmic Buprenorphine Belbuca An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Bupropion Aplenzin Increased risk of seizures Details Ofloxacin Ophthalmic Canagliflozin Invokana Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Ceritinib Zykadia An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Chloroquine Aralen® An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Chlorpromazine An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Chlorpropamide Diabinese® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Cholera Vaccine, Live Reduced immune response to the cholera vaccine Details Ofloxacin Ophthalmic Ciprofloxacin An increased risk of fluoroquinolones-related adverse reactions and an increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Citalopram Celexa An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Clarithromycin Biaxin An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Clofazimine An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Clomipramine Anafranil An increased risk of QT interval prolongation and an increased risk of seizures Details Ofloxacin Ophthalmic Clothiapine Increased risk of cardiac arrhythmias Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.