Ofloxacin Ophthalmic

337 interactions 674 cited references

Also sold as: Ocuflox Ocuflox®

About Ofloxacin Ophthalmic

Ophthalmic ofloxacin ophthalmic is used to treat bacterial infections of the eye, including conjunctivitis (pink eye) and ulcers of the cornea. Ofloxacin is in a class of medications called quinolone antibiotics. It works by killing bacterial cells that cause infection. Read the full Ofloxacin Ophthalmic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levoketoconazole Mesoridazine Pimozide Piperaquine Saquinavir Bepridil

12 Contraindicated 240 Major 84 Moderate 1 Minor

All (337) Contraindicated (12) Major (240) Moderate (84) Minor (1)

Major

Ofloxacin Ophthalmic Clozapine Clozaril Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Corticotropin An increased risk of tendon rupture Details Ofloxacin Ophthalmic Cortisone An increased risk of tendon rupture Details Ofloxacin Ophthalmic Cosyntropin An increased risk of tendon rupture Details Ofloxacin Ophthalmic Crizotinib Xalkori An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Cyclobenzaprine Amrix An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Dabrafenib Tafinlar An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Dapagliflozin Farxiga Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Dasatinib Phyrago An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Deflazacort Emflaza An increased risk of tendon rupture Details Ofloxacin Ophthalmic Degarelix Firmagon Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Delamanid Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Desflurane Suprane An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Desipramine Norpramin An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Dexamethasone An increased risk of tendon rupture Details Ofloxacin Ophthalmic Dexmedetomidine Dexased Increased risk of cardiac arrhythmias Details Ofloxacin Ophthalmic Disopyramide Norpace An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Dofetilide Tikosyn An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Ophthalmic Dolasetron Anzemet An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Domperidone Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Donepezil Adlarity Increased risk of QT-interval prolongation and torsade de pointes Details Ofloxacin Ophthalmic Dordaviprone An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Doxepin Prudoxin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Ophthalmic Droperidol An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Dulaglutide Trulicity Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Efavirenz An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Encorafenib Braftovi Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Ertugliflozin Steglatro Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Erythromycin Erythrocin Stearate Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Escitalopram Lexapro An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Etrasimod Velsipity Increased risk of transient reduction in heart rate, AV conduction, QT interval prolongation and an increased risk of torsade de p... Details Ofloxacin Ophthalmic Exenatide Bydureon Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Fexinidazole An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Fingolimod Gilenya Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Flecainide Tambocor® An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Fluconazole Diflucan An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Fludrocortisone An increased risk of tendon rupture Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.