Ofloxacin Ophthalmic

337 interactions 674 cited references

Also sold as: Ocuflox Ocuflox®

About Ofloxacin Ophthalmic

Ophthalmic ofloxacin ophthalmic is used to treat bacterial infections of the eye, including conjunctivitis (pink eye) and ulcers of the cornea. Ofloxacin is in a class of medications called quinolone antibiotics. It works by killing bacterial cells that cause infection. Read the full Ofloxacin Ophthalmic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levoketoconazole Mesoridazine Pimozide Piperaquine Saquinavir Bepridil

12 Contraindicated 240 Major 84 Moderate 1 Minor

All (337) Contraindicated (12) Major (240) Moderate (84) Minor (1)

Moderate

Ofloxacin Ophthalmic Lanthanum Carbonate Fosrenol Reduced bioavailability of quinolone antibiotics Details Ofloxacin Ophthalmic Lornoxicam An increased risk of seizures Details Ofloxacin Ophthalmic Loxoprofen An increased risk of seizures Details Ofloxacin Ophthalmic Lumiracoxib An increased risk of seizures Details Ofloxacin Ophthalmic Magaldrate Decreased oral ofloxacin effectiveness Details Ofloxacin Ophthalmic Magnesium Carbonate Decreased oral ofloxacin effectiveness Details Ofloxacin Ophthalmic Magnesium Hydroxide Almacone® (containing Aluminum Hydroxide, Magnesium Hydroxide, Simethicone) Decreased oral ofloxacin effectiveness Details Ofloxacin Ophthalmic Magnesium Oxide Mag-Ox 400 Decreased oral ofloxacin effectiveness Details Ofloxacin Ophthalmic Magnesium Trisilicate Decreased oral ofloxacin effectiveness Details Ofloxacin Ophthalmic Meclofenamate Meclodium® An increased risk of seizures Details Ofloxacin Ophthalmic Mefenamic Acid Ponstel® An increased risk of seizures Details Ofloxacin Ophthalmic Meloxicam Alloxate An increased risk of seizures Details Ofloxacin Ophthalmic Morniflumate An increased risk of seizures Details Ofloxacin Ophthalmic Nabumetone Relafen An increased risk of seizures Details Ofloxacin Ophthalmic Naproxen Aleve An increased risk of seizures Details Ofloxacin Ophthalmic Nepafenac Ilevro An increased risk of seizures Details Ofloxacin Ophthalmic Niflumic Acid An increased risk of seizures Details Ofloxacin Ophthalmic Nimesulide An increased risk of seizures Details Ofloxacin Ophthalmic Nimesulide Beta Cyclodextrin An increased risk of seizures Details Ofloxacin Ophthalmic Oxaprozin Coxanto An increased risk of seizures Details Ofloxacin Ophthalmic Oxyphenbutazone An increased risk of seizures Details Ofloxacin Ophthalmic Parecoxib An increased risk of seizures Details Ofloxacin Ophthalmic Phenylbutazone Equi-Phar An increased risk of seizures Details Ofloxacin Ophthalmic Piketoprofen An increased risk of seizures Details Ofloxacin Ophthalmic Piroxicam Feldene An increased risk of seizures Details Ofloxacin Ophthalmic Proglumetacin An increased risk of seizures Details Ofloxacin Ophthalmic Propionic Acid An increased risk of seizures Details Ofloxacin Ophthalmic Propyphenazone An increased risk of seizures Details Ofloxacin Ophthalmic Proquazone An increased risk of seizures Details Ofloxacin Ophthalmic Quercetin Reduced fluoroquinolone effectiveness Details Ofloxacin Ophthalmic Rofecoxib An increased risk of seizures Details Ofloxacin Ophthalmic Salicylic Acid An increased risk of seizures Details Ofloxacin Ophthalmic Salsalate Disalcid An increased risk of seizures Details Ofloxacin Ophthalmic Sodium Salicylate An increased risk of seizures Details Ofloxacin Ophthalmic Strontium Ranelate Decreased bioavailability and exposure of strontium ranelate Details Ofloxacin Ophthalmic Sucralfate Carafate Decreased ofloxacin effectiveness Details Ofloxacin Ophthalmic Sulindac Clinoril® An increased risk of seizures Details Ofloxacin Ophthalmic Tenoxicam An increased risk of seizures Details Ofloxacin Ophthalmic Tiaprofenic Acid An increased risk of seizures Details Ofloxacin Ophthalmic Tolfenamic Acid An increased risk of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.