Ofloxacin Ophthalmic

337 interactions 674 cited references
Also sold as: Ocuflox Ocuflox®
About Ofloxacin Ophthalmic

Ophthalmic ofloxacin ophthalmic is used to treat bacterial infections of the eye, including conjunctivitis (pink eye) and ulcers of the cornea. Ofloxacin is in a class of medications called quinolone antibiotics. It works by killing bacterial cells that cause infection. Read the full Ofloxacin Ophthalmic drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levoketoconazole Mesoridazine Pimozide Piperaquine Saquinavir Bepridil
12 Contraindicated 240 Major 84 Moderate 1 Minor
All (337) Contraindicated (12) Major (240) Moderate (84) Minor (1)

Major

Ofloxacin Ophthalmic Fluocortolone An increased risk of tendon rupture Details Ofloxacin Ophthalmic Fluoxetine RECONCILE An increased risk of QT interval prolongation and an increased risk of torsades de pointes Details Ofloxacin Ophthalmic Formoterol Perforomist Increased risk of QT interval prolongation and an increased risk of cardiovascular adverse effects Details Ofloxacin Ophthalmic Foscarnet Foscavir Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Fosfomycin Contepo An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Fosphenytoin Cerebyx An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Fostemsavir Rukobia Increased risk of torsade de pointes Details Ofloxacin Ophthalmic Gatifloxacin Zymaxid An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Gemifloxacin Factive An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Gepirone Exxua An increased risk of QT interval prolongation and cardiac arrhythmias Details Ofloxacin Ophthalmic Gepotidacin Blujepa An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Givinostat Duvyzat Increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Ophthalmic Glasdegib Daurismo Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Glimepiride Amaryl Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Glipizide Glucotrol Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Glyburide DiaBeta® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Goserelin Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Granisetron An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Halofantrine An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Haloperidol An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Histrelin Supprelin Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Hydrocortisone Ala-Cort An increased risk of tendon rupture Details Ofloxacin Ophthalmic Hydroxychloroquine Plaquenil An increased risk of seizures and an increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Hydroxyzine An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Ibutilide Corvert An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Ophthalmic Iloperidone Fanapt An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Imipramine An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Inotuzumab Ozogamicin Besponsa Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Insulin Afrezza Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Insulin Aspart, Recombinant Fiasp Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Insulin Bovine Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Insulin Degludec Tresiba Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Insulin Detemir Levemir Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Insulin Glulisine Apidra Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Insulin Lispro, Recombinant Admelog Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Isoflurane Fluriso An increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Ophthalmic Itraconazole Sporanox An increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Ophthalmic Ivosidenib Tibsovo An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Ketoconazole Extina Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Lapatinib Tykerb An increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.