Ofloxacin Ophthalmic

337 interactions 674 cited references

Also sold as: Ocuflox Ocuflox®

About Ofloxacin Ophthalmic

Ophthalmic ofloxacin ophthalmic is used to treat bacterial infections of the eye, including conjunctivitis (pink eye) and ulcers of the cornea. Ofloxacin is in a class of medications called quinolone antibiotics. It works by killing bacterial cells that cause infection. Read the full Ofloxacin Ophthalmic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levoketoconazole Mesoridazine Pimozide Piperaquine Saquinavir Bepridil

12 Contraindicated 240 Major 84 Moderate 1 Minor

All (337) Contraindicated (12) Major (240) Moderate (84) Minor (1)

Major

Ofloxacin Ophthalmic Insulin Afrezza Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Insulin Aspart, Recombinant Fiasp Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Insulin Bovine Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Insulin Degludec Tresiba Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Insulin Detemir Levemir Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Insulin Glulisine Apidra Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Insulin Lispro, Recombinant Admelog Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Isoflurane Fluriso An increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Ophthalmic Itraconazole Sporanox An increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Ophthalmic Ivosidenib Tibsovo An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Ketoconazole Extina Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Lapatinib Tykerb An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Lefamulin Xenleta Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Ofloxacin Ophthalmic Leuprolide Eligard Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Levofloxacin Levaquin Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Linagliptin Tradjenta Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Liraglutide Saxenda Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Lixisenatide Changes in blood glucose with an increased risk of hypoglycemia or hyperglycemia and delayed therapeutic effect of antibiotic Details Ofloxacin Ophthalmic Lofexidine Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Lonafarnib Zokinvy An increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Ophthalmic Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Ofloxacin Ophthalmic Lopinavir Increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Ophthalmic Lumefantrine An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Macimorelin Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Magnesium Sulfate May reduce absorption of fluoroquinolone antibiotics Details Ofloxacin Ophthalmic Mavorixafor Xolremdi An increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Ophthalmic Mefloquine Lariam® An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Metformin Fortamet® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Methadone Diskets Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Ofloxacin Ophthalmic Methylprednisolone Depo-Medrol An increased risk of tendon rupture Details Ofloxacin Ophthalmic Metronidazole Flagyl An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Mifepristone Korlym An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Miglitol Glyset® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Milsaperidone An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Mirtazapine Mirataz Increased risk of QT interval prolongation and torsades de pointes Details Ofloxacin Ophthalmic Mobocertinib Exkivity An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Moricizine An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Moxifloxacin Avelox Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.