Ofloxacin Ophthalmic

337 interactions 674 cited references

Also sold as: Ocuflox Ocuflox®

About Ofloxacin Ophthalmic

Ophthalmic ofloxacin ophthalmic is used to treat bacterial infections of the eye, including conjunctivitis (pink eye) and ulcers of the cornea. Ofloxacin is in a class of medications called quinolone antibiotics. It works by killing bacterial cells that cause infection. Read the full Ofloxacin Ophthalmic drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Levoketoconazole Mesoridazine Pimozide Piperaquine Saquinavir Bepridil

12 Contraindicated 240 Major 84 Moderate 1 Minor

All (337) Contraindicated (12) Major (240) Moderate (84) Minor (1)

Major

Ofloxacin Ophthalmic Ozanimod Additive effects on heart rate Details Ofloxacin Ophthalmic Pacritinib Vonjo® An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Paliperidone Erzofri Increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Ophthalmic Panobinostat Farydak Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Paroxetine Paxil An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Pasireotide Signifor Increased risk of QT prolongation Details Ofloxacin Ophthalmic Pazopanib Votrient Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Phenobarbital Fidoquel An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Pimavanserin Nuplazid An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Pioglitazone Actos Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Pitolisant Wakix Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Ponesimod Ponvory An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Porfimer Excessive intracellular damage in photosensitized tissues Details Ofloxacin Ophthalmic Posaconazole Noxafil An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Pramlintide Symlin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Prednisolone Flo-Pred® An increased risk of tendon rupture Details Ofloxacin Ophthalmic Prednisone Deltasone An increased risk of tendon rupture Details Ofloxacin Ophthalmic Primidone Mysoline An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Procainamide Procan® An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Prochlorperazine An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Promethazine Phenadoz An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Protriptyline An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Quetiapine Seroquel An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Quinidine Cardioquin® An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Quinine An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Quizartinib Vanflyta An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Ranolazine Aspruzyo An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Rasagiline Azilect Increased rasagiline exposure Details Ofloxacin Ophthalmic Relugolix Orgovyx Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Repaglinide Prandin® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Revumenib Revuforj An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Ribociclib Kisqali An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Rilpivirine Edurant An increased risk of QT interval prolongation and torsade de pointes Details Ofloxacin Ophthalmic Rosiglitazone Avandia® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Saxagliptin Onglyza Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Selpercatinib Retevmo Increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Semaglutide Ozempic Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Ofloxacin Ophthalmic Sematilide An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Ofloxacin Ophthalmic Sertraline An increased risk of QT interval prolongation Details Ofloxacin Ophthalmic Sevoflurane Petrem Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.