Ofloxacin

386 interactions 674 cited references

Also sold as: Floxin® Ocuflox

About Ofloxacin

Ofloxacin is a fluoroquinolone antibiotic used to treat bacterial infections including pneumonia, skin infections, and urinary tract infections. Read the full Ofloxacin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Bepridil Thioridazine Dronedarone Cisapride Terfenadine Ziprasidone

12 Contraindicated 277 Major 96 Moderate 1 Minor

All (386) Contraindicated (12) Major (277) Moderate (96) Minor (1)

Moderate

Ofloxacin Aspirin Acuprin® An increased risk of seizures Details Ofloxacin Aspirin Rectal Aspirin An increased risk of seizures Details Ofloxacin Bromfenac Ophthalmic Bromday® An increased risk of seizures Details Ofloxacin Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of seizures Details Ofloxacin Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of seizures Details Ofloxacin Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of seizures Details Ofloxacin Diclofenac Transdermal Patch Flector An increased risk of seizures Details Ofloxacin Didanosine Videx® Decreased ofloxacin bioavailability and potential loss of ofloxacin efficacy Details Ofloxacin Etodolac Lodine An increased risk of seizures Details Ofloxacin Fenoprofen Fenopron An increased risk of seizures Details Ofloxacin Flurbiprofen Ansaid An increased risk of seizures Details Ofloxacin Flurbiprofen Ophthalmic Ocufen An increased risk of seizures Details Ofloxacin Ibuprofen Addaprin An increased risk of seizures Details Ofloxacin Ketoprofen Actron® An increased risk of seizures Details Ofloxacin Ketorolac Acular An increased risk of seizures Details Ofloxacin Ketorolac Injection Acular An increased risk of seizures Details Ofloxacin Ketorolac Nasal Spray Sprix An increased risk of seizures Details Ofloxacin Ketorolac Ophthalmic Acular An increased risk of seizures Details Ofloxacin Lanthanum Fosrenol® Reduced bioavailability of quinolone antibiotics Details Ofloxacin Meclofenamate Meclodium® An increased risk of seizures Details Ofloxacin Mefenamic Acid Ponstel® An increased risk of seizures Details Ofloxacin Meloxicam Alloxate An increased risk of seizures Details Ofloxacin Meloxicam Injection Alloxate An increased risk of seizures Details Ofloxacin Nabumetone Relafen An increased risk of seizures Details Ofloxacin Naproxen Aleve An increased risk of seizures Details Ofloxacin Aceclofenac An increased risk of seizures Details Ofloxacin Acemetacin An increased risk of seizures Details Ofloxacin Aluminum Carbonate, Basic Decreased oral ofloxacin effectiveness Details Ofloxacin Aluminum Hydroxide AlternaGEL® Decreased oral ofloxacin effectiveness Details Ofloxacin Aluminum Phosphate Decreased oral ofloxacin effectiveness Details Ofloxacin Aminolevulinic Acid Increased risk of phototoxic skin reaction (ie, severe sunburn) Details Ofloxacin Amtolmetin Guacil An increased risk of seizures Details Ofloxacin Bromfenac Bromsite An increased risk of seizures Details Ofloxacin Bufexamac An increased risk of seizures Details Ofloxacin Calcium Decreased oral ofloxacin effectiveness Details Ofloxacin Celecoxib Celebrex An increased risk of seizures Details Ofloxacin Choline Salicylate An increased risk of seizures Details Ofloxacin Clonixin An increased risk of seizures Details Ofloxacin Dandelion Decreased fluoroquinolone effectiveness Details Ofloxacin Dexibuprofen An increased risk of seizures Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.